Publications
Link to the Google Scholar profile of Tobias Lenz
Peer-Reviewed Publications
(* - equal contribution, members of the lab)
2023
Vinkler M, Fiddaman SR, Tesický M, O'Connor EA, Savage AE, Lenz TL, Smith AL, Kaufman J, Bolnick D, Davies CS, Dedic N, Flies AS, Samblás MMG, Henschen A, Novák K, Palomar G, Raven N, Samake K, Slade J, Veetil NK, Voukali E, Höglund J, Richardson DS, Westerdahl H (In press) Understanding the evolution of immune genes in jawed vertebrates. Journal of Evolutionary Biology.
Pohlmann A, Stejska O, King J, Bouwhuis S, Packmor F, Ballstaedt E, Hälterlein B, Hennig V, Stacker L, Graaf A, Hennig C, Günther A, Liang Y, Hjulsager C, Beer M, Harder T (In press) Mass mortality among colony-breeding seabirds in the German Wadden Sea in 2022 due to at least two regionally circulating, distinct genotypes of HPAIV H5N1 clade. Journal of General Virology.
Sakaue S, Gurajala S, Curtis M, Luo Y, Choi W, Ishigaki K, Kang JB, Rumker L, Deutsch AJ, Schönherr S, Lukas Forer L, LeFaive J, Fuchsberger C, Han B, Lenz TL, de Bakker PIW, Okada Y, Smith AV, Raychaudhuri S (In press) A statistical genetics guide to identifying HLA alleles driving complex disease. Nature Protocols.
Gaigher A, Rota A, Neves F, Muñoz-Mérida A, Blasco-Aróstegui J, Almeida T, Veríssimo A (2023) Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula). Scientific Reports 13: 3837.
Barth JMI, Handley SA, Kintzl D, Leonard G, Malinsky M, Matschiner M, Meyer BS, Salzburger W, Stefka S, Trucchi E (2023) The history and organization of the Workshop on Population and Speciation Genomics. Evolution: Education and Outreach 16: 2.
ElAbd H, Bacher P, Tholey A, Lenz TL, Franke A (2023) Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins. Frontiers in Immunology 14: 1107266.
Wichers-Misterek J, Binder A, Mesén-Ramírez P, Dorner LP, Safavi S, Fuchs G, Lenz TL, Bachmann A, Wilson D, Frischknecht F, Gilberger T (2023) A microtubule associated protein is essential for malaria parasite transmission. mBio 14: e03318-22.
2022
Neves F, Munoz-Merida A, Machado AM, Almeida T, Gaigher A, Esteves PJ, Castro LFC, Verissimo A (2022) Uncovering a 500 million year old history and evidence of pseudogenization for TLR15. Frontiers in Immunology 13: 1020601.
Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Ortiz AB, Salazar A, Chercoles AG, Palom A, Ruiz A, Garcia-Fernandez A, Blanco-Grau A, Mantovani A, Zanella A, Holten AR, Mayer A, Bandera A, Cherubini A, Protti A, Aghemo A, Gerussi A, Ramirez A, Braun A, Nebel A, Barreira A, Lleo A, Teles A, Kildal AB, Biondi A, Caballero-Garralda A, Ganna A, Gori A, Glück A, Lind A, Tanck A, Hinney A, Nolla AC, Fracanzani AL, Peschuck A, Cavallero A, Dyrhol-Riise AM, Ruello A, Julià A, Muscatello A, Pesenti A, Voza A, Rando-Segura A, Solier A, Schmidt A, Cortes B, Mateos B, Nafria-Jimenez B, Schaefer B, Jensen B, Bellinghausen C, Maj C, Ferrando C, Horra C, Quereda C, Skurk C, Thibeault C, Scollo C, Herr C, Spinner CD, Gassner C, Lange C, Hu C, Paccapelo C, Lehmann C, Angelini C, Cappadona C, Azuure C, COVICAT study group, Aachen Study (COVAS), Bianco C, Cea C, Sancho C, Hoff DAL, Galimberti D, Prati D, Haschka D, Jiménez D, Pestaña D, Toapanta D, Muñiz-Diaz E, Azzolini E, Sandoval E, Binatti E, Scarpini E, Helbig ET, Casalone E, Urrechaga E, Paraboschi EM, Pontali E, Reverter E, Calderón EJ, Navas E, Solligård E, Contro E, Arana-Arri E, Aziz F, Garcia F, Sánchez FG, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Kurth F, Blasi F, Malvestiti F, Medrano FJ, Mesonero F, Rodriguez-Frias F, Hanses F, Müller F, Hemmrich-Stanisak G, Bellani G, Grasselli G, Pezzoli G, Costantino G, Albano G, Cardamone G, Bellelli G, Citerio G, Foti G, Lamorte G, Matullo G, Baselli G, Kurihara H, Neb H, My I, Kurth I, Hernández I, Pink I, Rojas I, Galván-Femenia I, Holter JC, Afset JE, Heyckendorf J, Kässens J, Damås JK, Rybniker J, Altmüller J, Ampuero J, Martín J, Erdmann J, Banales JM, Badia JR, Dopazo J, Schneider J, Bergan J, Barretina J, Walter J, Quero JH, Goikoetxea J, Delgado J, Guerrero JM, Fazaal J, Kraft J, Schröder J, Risnes K, Banasik K, Müller KE, Gaede KI, Garcia-Etxebarria K, Tonby K, Heggelund L, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Sander LE, Lippert LJ, Terranova L, Nkambule L, Knopp L, Gustad LT, Garbarino L, Santoro L, Téllez L, Roade L, Ostadreza M, Intxausti M, Kogevinas M, Riveiro-Barciela M, Berger MM, Schaefer M, Niemi MEK, Gutiérrez-Stampa MA, Carrabba M, Basso MEF, Valsecchi MG, Hernandez-Tejero M, Vehreschild MJGT, Manunta M, Acosta-Herrera M, D'Angiò M, Baldini M, Cazzaniga M, Grimsrud MM, Cornberg M, Nöthen MM, Marquié M, Castoldi M, Cordioli M, Cecconi M, D'Amato M, Augustin M, Tomasi M, Boada M, Dreher M, Seilmaier MJ, Joannidis M, Wittig M, Mazzocco M, Ciccarelli M, Rodríguez-Gandía M, Bocciolone M, Miozzo M, Ayo NI, Blay N, Chueca N, Montano N, Braun N, Ludwig N, Marx N, Martínez N, Norwegian SARS-CoV-2 Study group, Cornely OA, Witzke O, Palmieri O, Group PS, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, España PP, Hoffmann P, Rosenstiel P, Schommers P, Suwalski P, Pablo R, Ferrer R, Bals R, Gualtierotti R, Gallego-Durán R, Nieto R, Carpani R, Morilla R, Badalamenti S, Haider S, Ciesek S, May S, Bombace S, Marsal S, Pigazzini S, Klein S, Pelusi S, Wilfling S, Bosari S, Volland S, Brunak S, Raychaudhuri S, Schreiber S, Heilmann-Heimbach S, Aliberti S, Ripke S, Dudman S, Wesse T, Zheng T, The STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force, Bahmer T, Eggermann T, Illig T, Brenner T, Pumarola T, Feldt T, Folseraas T, Cejudo TG, Landmesser U, Protzer U, Hehr U, Rimoldi V, Monzani V, Skogen V, Keitel V, Kopfnagel V, Friaza V, Andrade V, Moreno V, Albrecht W, Peter W, Poller W, Farre X, Yi X, Wang X, Khodamoradi Y, Karadeniz Z, Latiano A, Goerg S, Bacher P, Koehler P, Tran F, Zoller H, Schulte EC, Heidecker B, Ludwig KU, Fernández J, Romero-Gómez M, Albillos A, Invernizzi P, Buti M, Duga S, Bujanda L, Hov JR*, Lenz TL*, Asselta R*, de Cid R*, Valenti L*, Karlsen TH*, Cáceres M*, Franke A* (2022) Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Human Molecular Genetics 31: 3945-3966.
Huang W, Wang X, Liu B, Lenz TL, Peng Y, Dong L, Zhang Y (2022) Evaluation of genetic diversity and parasite-mediated selection of MHC class I genes in Emberiza godlewskii (Passeriformes: Emberizidae). Diversity 14: 925.
Tebbe J, Ottensmann M, Havenstein K, Efstratiou A, Lenz TL, Caspers BA., Forcada J, Tiedemann R, Hoffman JI (2022) Intronic primers reveal unexpectedly high major histocompatibility complex diversity in Antarctic fur seals. Scientific Reports 12: 17933.
Pagliuca S, Gurnari C, Rubio MT, Visconte V, Lenz TL (2022) Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond. Frontiers in Immunology 13: 944872.
Chowell D, Yoo S-K, Valero C, Pastore A, Krishna C, Lee M, Hoen D, Shi H, Kelly DW, Patel N, Makarov V, Ma X, Vuong L, Sabio EY, Weiss K, Kuo F, Lenz TL, Samstein RM, Riaz N, Adusumilli PS, Balachandran VP, Plitas G, Hakimi AA, Abdel-Wahab O, Shoushtari AN, Postow MA, Motzer RJ, Ladanyi M, Zehir A, Berger MF, Gönen M, Morris LGT, Weinhold N, Chan TA (2022) An integrated clinical-genetic model for accurate prediction of immune checkpoint blockade efficacy across multiple cancer types. Nature Biotechnology 40: 499-506.
Purde M-T, Niederer R, Wagner NB, Diem S, Berner F, Hasan Ali O, Hillmann D, Bergamin I, Joerger M, Risch M, Niederhauser C, Lenz TL, Früh M, Risch L, Semela D, Flatz L (2022) Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients. Journal of Cancer Research and Clinical Oncology 148: 647-656.
2021
COVID-19 Host Genetics Initiative (2021) Mapping the human genetic architecture of COVID-19. Nature 600: 472-477.
Pagliuca S, Gurnari C, Awada H, Kishtagari A, Kongkiatkamon S, Terkawi L, Zawit M, Guan Y, LaFramboise T, Jha BK, Patel BJ, Hamilton BK, Majhail NS, Lundgren S, Mustjoki S, Saunthararajah Y, Visconte V, Chan T, Yang C-Y, Lenz TL*, Maciejewski JP* (2021) The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders. Blood 138: 2781-2798.
Berner F, Niederer R, Luimstra J, Pop OT, Jochum A-K, Purde M-T, Hasan Ali O, Bomze D, Bauer J, Freudenmann LK, Marcu A, Wolfschmitt E-M, Haen S, Gross T, Dubbelaar ML, Abdou M-T, Baumgartner P, MS Appenzeller C, Cicin-Sain C, Lenz TL, Speiser DE, Ludewig B, Driessen C, Jörger M, Früh M, Jochum W, Cozzio A, Rammensee H-G, Walz J, Neefjes J, Flatz L (2021) Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival. OncoImmunology 10:1.
El Abd H, Degenhardt F, Koudelka T, Kamps A-K, Tholey A, Bacher P, Lenz TL, Franke A, Wendorff M (2021) Immunopeptidomics Toolkit Library (IPTK): A Python-based Modular Toolbox for Analyzing Immunopeptidomics Data. BMC Bioinformatics 22: 405.
Özer O, Lenz TL (2021) Unique pathogen peptidomes facilitate pathogen-specific selection and specialization of MHC alleles. Molecular Biology and Evolution 38: 4376-4387.
Haller M, Bonczarowska JH, Rieger D, Lenz TL, Nebel A, Krause-Kyora B (2021) Ancient DNA study in medieval Europeans shows an association between HLA-DRB1*03 and paratyphoid fever. Frontiers in Immunology 12: 2802
Degenhardt F, Mayr G, Wendorff M, Boucher G, Ellinghaus E, Ellinghaus D, ElAbd H, Rosati E, Hübenthal M, Juzenas S, Abedian S, Vahedi H, Thelma BK, Yang S, Ye BD, Cheon JH, Datta LW, Daryani NE, Ellul P, Esaki M, Fuyuno Y, McGovern DPB, Haritunians T, Hong M, Juyal G, Jung ES, Kubo M, Kugathasan S, Lenz TL, Leslie S, Malekzadeh R, Midha V, Motyer A, Ng SC, Okou DT, Raychaudhuri S, Schembri J, Schreiber S, Song K, Sood A, Takahashi A, Torres EA, Umeno J, Alizadeh BZ, Weersma RK, Wong SH, Yamazaki K, Karlsen TH, Rioux JD, Brant SR, Franke A (In press) Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations. Human Molecular Genetics 30: 356-369.
Immel A, Pierini F, Rinne C, Meadows J, Barquera R, Szolek A, Susat J, Böhme L, Dose J, Bonczarowska J, Drummer C, Fuchs K, Ellinghaus D, Kässens JC, Furholt M, Kohlbacher O, Schade-Lindig S, Franke A, Krause J, Müller J, Lenz TL, Nebel A, Krause-Kyora B (2021) Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry. Communications Biology 4, 113.
Koneczny I, Yilmaz V, Lazaridis K, Tzartos J, Lenz TL, Tzartos SJ, Tüzün E, Leypoldt F (2021) Common denominators in the immunobiology of IgG4 autoimmune diseases: What do glomerulonephritis, pemphigus vulgaris, myasthenia gravis, thrombotic thrombocytopenic purpura and autoimmune encephalitis have in common? Frontiers in Immunology 11, 605214.
2020
Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta RA, Grimsrud MM, Milani C, Aziz FA, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez A-E, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo A, Lleo A, Biondi A, Caballero-Garralda A, Gori A, Tanck A, Nolla AC, Latiano A, Fracanzani AL, Peschuck A, Julià A, Pesenti A, Voza A, Jiménez D, Mateos B, Jimenez BN, Quereda C, Paccapelo C, Gassner C, Angelini C, Cea C, Solier A, Pestaña D, Muñiz-Diaz E, Sandoval E, Paraboschi EM, Navas E, Sánchez FG, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Blasi F, Téllez L, Blanco-Grau A, Hemmrich-Stanisak G, Grasselli G, Costantino G, Cardamone G, Foti G, Aneli S, Kurihara H, ElAbd H, My I, Galván-Femenia I, Martin J, Erdmann J, Ferrusquía-Acosta J, Garcia-Etxebarria K, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Terranova L, Moreira L, Santoro L, Scudeller L, Mesonero F, Roade L, Rühlemann MC, Schaefer M, Carrabba M, Riveiro-Barciela M, Basso MEF, Valsecchi MG, Hernandez-Tejero M, Acosta-Herrera M, D'Angiò M, Baldini M, Cazzaniga M, Schulzky M, Cecconi M, Wittig M, Ciccarelli M, Rodríguez-Gandía M, Bocciolone M, Miozzo M, Montano N, Braun N, Sacchi N, Martínez N, Özer O, Palmieri O, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, Ortiz AB, de Cid R, Ferrer R, Gualtierotti R, Nieto R, Goerg S, Badalamenti S, Marsal S, Matullo G, Pelusi S, Juzenas S, Aliberti S, Monzani V, Moreno V, Wesse T, Lenz TL, Pumarola T, Rimoldi V, Bosari S, Albrecht W, Peter W, Romero-Gómez M, D'Amato, M, Duga S, Banales JM, Hov JR, Folseraas T, Valenti L, Franke A, Karlsen TH (2020) Genome-wide association study in severe Covid-19 with respiratory failure. New England Journal of Medicine 383: 1522-1534.
Sagonas K, Meyer B, Kaufmann J, Lenz TL, Häsler R, Eizaguirre C (2020) Experimental parasite infection causes genome-wide changes in DNA methylation. Molecular Biology and Evolution 37: 2287-2299.
ElAbd H, Bromberg Y, Hoarfrost A, Lenz TL, Franke A, Wendorff M (2020) Amino Acid Encoding for Deep Learning Applications. BMC Bioinformatics 21: 235.
Pierini F, Nutsua M, Böhme L, Özer O, Bonczarowska J, Susat J, Franke A, Nebel A, Krause-Kyora B, Lenz TL (2020) Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations. Scientific Reports 10:7339.
Radwan J, Babik W, Kaufman J, Lenz TL, Winternitz J (2020) Advances in the evolutionary understanding of MHC polymorphism. Trends in Genetics 36: 298-311.
Arora J, Pierini F, McLaren PJ, Carrington M, Fellay J, Lenz TL (2020) HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation. Molecular Biology and Evolution 37: 639-650.
2019
Chowell D, Krishna C, Pierini F, Makarov V, Rizvi NA, Kuo F, Riaz N, Lenz TL*, Chan TA* (2019) Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine 25: 1715-1720.
Huang Y, Feulner PGD, Eizaguirre C, Lenz TL, Bornberg-Bauer E, Milinski M, Reusch TBH, Chain FJJ (2019) Genome-wide genotype-expression relationships reveal both copy number and single nucleotide differentiation contribute to differential gene expression between stickleback ecotypes. Genome Biology and Evolution 11: 2344-2359.
Degenhardt F, Wendorff M, Wittig M, Ellinghaus E, Datta LW, Schembri J, Ng SC, Rosati E, Hübenthal M, Ellinghaus D, Jung ES, Lieb W, Abedian S, Malekzadeh R, Cheon JH, Ellul P, Sood A, Midha V, Wong SH, Schreiber S, Yamazaki K, Kubo M, Boucher G, Rioux J, Lenz TL, Brant SR, Franke A (2019) Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles. Human Molecular Genetics 28: 2078-2092.
Manczinger M, Boross G, Kemény L, Müller V, Lenz TL, Papp B, Pál C (2019) Pathogen diversity drives the evolution of generalist antigen presentation in human populations. PLoS Biology 17: e3000131
Arora J, McLaren P.J, Chaturvedi N, Carrington M, Fellay J, Lenz TL (2019) HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control. Proceedings of the National Academy of Sciences of the United States of America 116: 944-949.
Hasan Ali O, Berner F, Bomze D, Faessler M, Diem S, Cozzio A, Joerger M, Frueh M, Driessen C, Lenz TL*, Flatz L* (2019) Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors. European Journal of Cancer 107: 8-14.
2018
Lenz TL, Hafer N, Samonte-Padilla I, Yeates SE, Milinski M (2018) Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immunogenes. Evolution 72: 2478-2490.
Pierini F, Lenz TL (2018) Divergent allele advantage at human MHC genes: signatures of past and ongoing selection. Molecular Biology and Evolution 35: 2145-2158.
Krause-Kyora B, Nutsua M, Böhme L, Pierini F, Pedersen DD, Kornell S-C, Drichel D, Bonazzi M, Möbus L, Tarp P, Susat J, Bosse E, Willburger B, Schmidt AH, Sauter J, Franke A, Wittig M, Calibe A, Nothnagel M, Schreiber S, Boldsen J*, Lenz TL*, Nebel A* (2018) Ancient DNA study reveals HLA susceptibility loci for leprosy in medieval Europeans. Nature Communications 9: 1569.
Lenz TL (2018) Adaptive value of novel MHC immune gene variants [Invited Commentary]. Proceedings of the National Academy of Sciences of the United States of America 115: 1414-1416.
2017
Calvignac-Spencer S, Lenz TL (2017) The One Past Health workshop - Connecting ancient DNA and zoonosis research [Meeting Report]. BioEssays 39: 1700075.
Kaufmann J, Lenz TL, Kalbe M, Milinski M, Eizaguirre C (2017) A field reciprocal transplant experiment reveals asymmetric costs of migration between lake and river ecotypes of three-spined sticklebacks (Gasterosteus aculeatus). Journal of Evolutionary Biology 30: 938-950.
2016
Lenz TL, Spirin V, Jordan DM, Sunyaev SR (2016) Excess of deleterious mutations around HLA immune genes reveals evolutionary cost of balancing selection. Molecular Biology and Evolution 33: 2555-2564.
Savova V, Chun SG, Sohail M, McCole R, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA (2016) Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nature Genetics 48: 231-237.
Huang Y, Chain FJJ, Panchal M, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TBH, Milinski M, Feulner, PGD (2016) Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks. Molecular Ecology 25: 943-958.
2015
McLaren PJ*, Coulonges C*, Bartha I*, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro J, Mullins JI, Obel N, Poli G, Sandhu M, Schuitemaker H, Shea P, Theodorou I, Walker BD, Weintrob A, Winkler C, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PIW, Zagury J-F, Fellay J, for the International Collaboration for the Genomics of HIV (2015) Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proceedings of the National Academy of Sciences of the United States of America 112: 14658-14663.
Lenz TL (2015) Transcription in space – Environmental vs. genetic effects on differential immune gene expression [Perspective]. Molecular Ecology 24: 4583-4585.
Lenz TL*, Deutsch AJ*, Han B, Hu XY, Okada Y, Eyre S, Knapp M, Zhernakova A, Huizinga TWJ, Abecasis G, Becker J, Boeckxstaens GE, Chen W-M, Franke A, Gladman DD, Gockel I, Gutierrez-Achury J, Martin J, Nair RP, Nöthen MM, Onengut-Gumuscu S, Rahman P, Rantapää-Dahlqvist S, Stuart PE, Tsoi LC, Van Heel DA, Worthington J, Wouters MM, Klareskog L, Elder JT, Gregersen P, Schumacher J, Rich SS, Wijmenga C, Sunyaev SR, de Bakker PIW, Raychaudhuri S (2015) Widespread non-additive and interaction effects within the HLA modulate the risk of autoimmune diseases. Nature Genetics 47: 1085-1090.
Hu XY*, Deutsch AJ*, Lenz TL, Onengut-Gumuscu S, Han B, Chen W.-M, Howson JM, Todd JA, de Bakker PIW, Rich SS, Raychaudhuri S (2015) Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nature Genetics 47: 898–905.
Feulner, PGD, Chain FJJ, Panchal M, Huang Y, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TBH, Milinski M (2015) Genomics of divergence along a continuum of parapatric population differentiation. PLoS Genetics 11: e1004966.
Kaufmann J, Eizaguirre C, Milinski M, Lenz TL (2015) The contribution of post-copulatory mechanisms to incipient ecological speciation in sticklebacks. Biology Letters 11: 20140933.
2014
Chain FJJ, Feulner PGD, Panchal M, Eizaguirre C, Samonte IE, Kalbe M, Lenz TL, Stoll M, Bornberg-Bauer E, Milinski M, Reusch TBH (2014) Extensive copy-number variation of young genes across stickleback populations. PLoS Genetics 10: e1004830.
Kaufmann J, Lenz TL, Milinski M, Eizaguirre C (2014) Experimental parasite infection reveals costs and benefits of paternal effects. Ecology Letters 17: 1409-1417.
2013
Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Yim SH, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee S, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Fang X, Wang J, Gladyshev VN (2013) Genome analysis reveals insights into the evolution, physiology, and longevity of the Brandt’s bat Myotis brandtii. Nature Communications 4: 2212.
Lenz TL, Eizaguirre C, Kalbe M, Milinski M (2013) Evaluating patterns of convergent evolution and trans-species polymorphism at MHC immunogenes in two sympatric stickleback species. Evolution 67: 2400-2412.
Lenz TL, Mueller B, Trillmich F, Wolf JBW (2013) Divergent allele advantage at MHC-DRB through direct and maternal genotypic effects and its consequences on allele pool composition and mate choice. Proceedings of the Royal Society of London: B 280: 20130714.
Lenz TL, Eizaguirre C, Rotter B, Kalbe M, Milinski M (2013) Exploring local immunological adaptation of two stickleback ecotypes by experimental infection and transcriptome-wide digital gene expression analysis. Molecular Ecology 22: 774-786.
Feulner PGD, Chain FJJ, Panchal M, Eizaguirre C, Kalbe M, Lenz TL, Mundry M, Samonte IE, Stoll M, Milinski M, Reusch TBH, Bornberg-Bauer E (2013) Genome-wide patterns of standing genetic variation in a marine population of three-spined sticklebacks. Molecular Ecology 22: 635-649.
2012
Eizaguirre C*, Lenz TL*, Kalbe M, Milinski M (2012) Divergent selection on locally adapted MHC immune genes experimentally proven in the field. Ecology Letters 15: 723-731.
Eizaguirre C, Lenz TL, Kalbe M, Milinski M (2012). Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations. Nature Communications 3: 621.
2011
Samonte-Padilla IE, Eizaguirre C, Scharsack JP, Lenz TL, Milinski M (2011) Induction of diploid gynogenesis in an evolutionary model system, the three-spined stickleback (Gasterosteus aculeatus). BMC Developmental Biology 11: 55.
Lenz TL (2011) Computational prediction of MHC II-antigen binding supports divergent allele advantage and explains trans-species polymorphism. Evolution 65: 2380-2390.
Lenz TL (2011) Uterine selection for immunocompetent offspring [letter]. Proceedings of the National Academy of Sciences of the United States of America 108: E253.
Eizaguirre C, Lenz TL, Sommerfeld RD, Harrod C, Kalbe M, Milinski M (2011) Parasite diversity, patterns of MHC II variation and olfactory based mate choice in diverging three-spined stickleback ecotypes. Evolutionary Ecology 25:605-622.
2010
Eizaguirre C, Lenz TL (2010) Invited review: Major histocompatibility complex polymorphism: Dynamics and consequences of parasite-mediated local adaptation in fishes. Journal of Fish Biology 77:2023–2047.
2009
Lenz TL, Wells K, Pfeiffer M, Sommer S (2009) Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus). BMC Evolutionary Biology 9:269.
Lenz TL, Eizaguirre C, Scharsack JP, Kalbe M, Milinski M (2009) Disentangling the role of MHC-dependent 'good genes' and 'compatible genes' in mate choice decisions of three-spined sticklebacks under semi-natural conditions. Journal of Fish Biology (special stickleback issue) 75:2122-2142.
Eizaguirre C, Yeates SE, Lenz TL, Kalbe M, Milinski M (2009) MHC-based mate choice combines good genes and maintenance of MHC polymorphism. Molecular Ecology 18:3316-3329.
Lenz TL, Eizaguirre C, Becker S, Reusch TBH (2009) RSCA genotyping of MHC for high-throughput evolutionary studies in the model organism three-spined stickleback Gasterosteus aculeatus. BMC Evolutionary Biology 9:57.
Eizaguirre C, Lenz TL, Traulsen A, Milinski M (2009) Speciation accelerated and stabilized by pleiotropic major histocompatibility complex immunogenes. Ecology Letters 12:5-12
2008
Lenz TL, Becker, S (2008) Simple approach to reduce PCR artefact formation leads to reliable genotyping of MHC and other highly polymorphic loci – implications for evolutionary analysis. Gene 427:117-123.
2007
Urbach, D, Bittner D, Lenz TL, Bernet D, Wahli T, Wedekind C (2007) Sperm velocity in an Alpine whitefish: effects of age, size, condition, fluctuating asymmetry and gonad abnormalities. Journal of Fish Biology 71:672-683.
Lenz TL, Jacob A, Wedekind C (2007) Manipulating sex ratio to increase population growth: the example of the Lesser Kestrel. Animal Conservation 10:236-244.