Publikationen
2023
Wirth S, Schlößer A, Beiersdorfer A, Schweizer M, Lohr C, Grochowska KM (2023) Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling. bioRxiv doi.org/10.1101/2023.09.04.556200
Lohr C (2023) Role of P2Y receptors in astrocyte physiology and pathophysiology. Neuropharmacology. 223:109311. doi: 10.1016/j.neuropharm.2022.109311.
Herbertz M, Lohr J, Lohr C, Dobler S (2023) Knockdown of Na,K-ATPase β-subunits in Oncopeltus fasciatus induces molting problems and alterations in tracheal morphology. Insect Science. 30:375-397. doi.org/10.1111/1744-7917.13117
2022
Hassani Nia F, Woike D, Bento I, Niebling S, Tibbe D, Schulz K , Hirnet D, Skiba M, Hönck HH, Veith K, Günther C, Scholz T, Bierhals T, Driemeyer J, Bend R, Failla A, Lohr C, Garcia Alai M, Kreienkamp HJ (2022) Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans. Mol. Psychiatry. doi.org/10.1038/s41380-022-01882-3
Schwarzenberg FL, Schütz P, Hammel JU, Riedel M, Bartl J, Bordbari S, Frank S-C, Walkenfort B, Busse M, Herzen J, Lohr C, Wülfing C, Henne S (2022) Three-dimensional analyzes of vascular network morphology in a murine lymph node by X-ray phase-contrast tomography with a 2D Talbot array. Front. Immunol. 13:947961 doi: 10.3389/fimmu.2022.947961.
Schubert C, Schulz K, Träger S, Plath AL, Omriouate A, Rosenkranz SC, Morellini F, Friese MA, Hirnet D (2022) Neuronal adenosine A1 receptor is critical for olfactory function but unable to attenuate olfactory dysfunction in neuroinflammation. Front. Cell. Neurosci. 16:912030. doi 10.3389/fncel.2022.912030
Matschke J, Lahann H, Krasemann S, Altmeppen H, Pfefferle S, Galliciotti G, Fitzek A, Sperhake J, Ondruschka B, Busch M, Rotermund N, Schulz K, Lohr C, Dottermusch M, Glatzel M (2022) Young COVID-19 patients show a higher degree of microglial activation when compared to controls. Front. Neurol. 13:908081. doi: 10.3389/fneur.2022.908081.
Boda E, Boscia F, Lohr C (2022) The role of astroglia and oligodendroglia in CNS development, plasticity and disease - novel tools and investigative approaches. Front. Cell. Neurosci. 16:901820. doi: 10.3389/fncel.2022.901820.
Herbertz M, Harder S, Lohr C, Dobler S (2022) Na,K-ATPase α1- and β-subunits show distinct localizations in the nervous tissue of the large milkweed bug. Cell Tiss. Res. 388:503-519. doi 10.1007/s00441-022-03580-6.
Fearey BC, Binkle L, Mensching D, Schulze C, Lohr C, Friese MA, Oertner TG, Gee CE (2022) A glibenclamide-sensitive TRPM4-mediated component of CA1 excitatory postsynaptic currents appears in experimental autoimmune encephalomyelitis. Sci. Rep. 12:6000. doi: 10.1038/s41598-022-09875-6.
2021
Fischer T , Prey J, Eschholz L, Rotermund N, Lohr C (2021) Norepinephrine-induced calcium signaling and store-operated calcium entry in olfactory bulb astrocytes. Front. Cell. Neurosci. 15:639754. doi: 10.3389/fncel.2021.639754.
Woelk LM, Kannabiran SA, Brock V, Gee CE, Lohr C, Guse AH, Diercks BP, Werner R (2021) Time-dependent image restoration of low-SNR live cell Ca2+ fluorescence microscopy data. Int. J. Mol. Sci. 22(21), 11792 doi.org/10.3390/ijms222111792.
Günther HS, Henne S, Oehlmann J, Urban J, Pleizier D, Renevier N, Lohr C, Wülfing C (2021) GFAP and desmin expression in lymphatic tissues leads to difficulties in distinguishing between glial and stromal cells. Sci. Rep. 11:13322. doi: 10.1038/s41598-021-92364-z.
Lohr C, Beiersdorfer A, Fischer T, Hirnet D, Rotermund N, Sauer J, Schulz K, Gee CE (2021) Using genetically encoded calcium indicators to study astrocyte physiology: A field guide. Front. Cell. Neurosci. doi: 10.3389/fncel.2021.690147.
Grohmann M, Schumacher M, Günther J, Singheiser SM, Nußbaum T, Wildner F, Gerevich Z, Jabs R, Hirnet D, Lohr C, Illes P, Schmalzing G, Franke H, Hausmann R (2021) BAC Transgenic Mice to Study the Expression of P2X2 and P2Y1 Receptors. Purin. Signal. doi: 10.1007/s11302-021-09792-9.
2020
Beiersdorfer A, Wolburg H, Grawe J, Scheller A, Kirchhoff F, Lohr C (2020). Sublamina-specific organization of the blood brain barrier in the mouse olfactory nerve layer. GLIA 68:631-645. doi: 10.1002/glia.23744.
Lopes AT, Hausrat TJ, Heisler FF, Gromova KV, Lombino FL, Fischer T, Ruschkies L, Breiden P, Thies E, Hermans-Borgmeyer I, Schweizer M, Schwarz JR, Lohr C, Kneussel M (2020). Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits. PLOS Biol. 18(8):e3000820. doi: 10.1371/journal.pbio.3000820.
Klein M, Lohr C*, Droste D* (2020). Age-dependent heterogeneity of murine olfactory bulb astrocytes. Front. Aging Neurosci. doi: 10.3389/fnagi.2020.00172. (*equal contribution).
Fischer T, Scheffler P, Lohr C (2020). Dopamine-induced calcium signaling in olfactory bulb astrocytes. Sci. Rep. 10:631. doi: 10.1038/s41598-020-57462-4.
2019
Beiersdorfer A, Lohr C (2019). AMPA receptor-mediated Ca2+ transients in mouse olfactory ensheathing cells. Front. Cell. Neurosci. 13:451. doi: 10.3389/fncel.2019.00451.
Rotermund N, Schulz K, Hirnet D, Lohr C (2019). Purinergic Signaling in the Vertebrate Olfactory System. Front. Cell. Neurosci. 13:112. doi: 10.3389/fncel.2019.00112.
Beiersdorfer A, Scheller A, Kirchhoff F, Lohr C (2019). Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca2+ transients and neurovascular coupling. GLIA 67:1385-1400. doi: 10.1002/glia.23613.
Fliegert R, Heeren J, Koch-Nolte F, Nikolaev V, Lohr C, Meier C, Guse AH (2019). Adenine nucleotides as paracrine mediators of and intracellular second messengers in immunity and inflammation. Biochem. Soc. Trans.47:329-337. doi: 10.1042/BST20180419.
2018
Schulz K, Rotermund N, Grzelka K, Benz J, Lohr C*, Hirnet D* (2018). Adenosine A1 receptor-mediated attenuation of reciprocal dendro-dendritic inhibition in the mouse olfactory bulb. Front. Cell. Neurosci. 11:435, doi: 10.3389/fncel.2017.00435. (*equal contribution).
Rotermund N, Winandy S, Fischer T, Schulz K, Fregin T, Breitkreutz N, Buchta M, Bartels J, Carlstrom M, Lohr C*, Hirnet D* (2018): Adenosine A1 receptor activates background potassium channels and modulates information processing in olfactory bulb mitral cells. J. Physiol. 596:717-733, doi: 10.1113/JP275503. (*equal contribution).
2017
Droste D, Seifert G, Seddar L, Jädtke O, Steinhäuser C, Lohr C (2017): Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes. Sci. Rep.7: 44817, srep44817.
2015
Stavermann M, Meuth P, Doengi M, Thyssen A, Deitmer JW, Lohr C (2015): Calcium-induced calcium release and gap junctions mediate large-scale calcium waves in olfactory ensheathing cells in situ. Cell Calcium 58:215-225.
Meka DP, Müller-Rischart AK, Nidadavolu P, Mohammadi B, Motori E, Ponna SK, Aboutalebi H, Bassal M, Annamneedi A, Finckh B, Miesbauer M, Rotermund N, Lohr C, Tatzelt J, Winklhofer KF, Kramer ER (2015): Parkin cooperates with GDNF/Ret signaling to prevent dopaminergic neuron degeneration. J. Clin. Invest. 125:1873-1885.
Rathgeber L, Gromova KV, Schaefer I, Breiden P, Lohr C, Kneussel M (2015): GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites. Eur. J. Cell Biol. 94:173-178.
Bluhm B, Laffer B, Hirnet D, Rothermundt M, Ambree O, Lohr C (2015): Normal cerebellar development in S100B-deficient mice. Cerebellum 14:119-127.
2014
Lohr C, Grosche A, Reichenbach A, Hirnet D (2014): Purinergic neuron-glia interactions in sensory systems. Pflugers Arch. 466:1859–1872.
2013
Thyssen A, Stavermann M, Buddrus K, Doengi M, Ekberg JA, St John JA, Deitmer JW, Lohr C (2013): Spatial and developmental heterogeneity of calcium signaling in olfactory ensheathing cells. GLIA 61:327-337.
2012
Stavermann M, Buddrus K, St John JA, Ekberg JA, Nilius B, Deitmer JW, Lohr C (2012): Temperature-dependent calcium-induced calcium release via InsP3 receptors in mouse olfactory ensheathing glial cells. Cell Calcium 52:113-123.
Fischer T, Rotermund N, Lohr C*, Hirnet D* (2012): P2Y1 receptor activation by photolysis of caged ATP enhances neuronal network activity in the developing olfactory bulb. Purin. Signal. 8:191-198. (*equal contribution).
2011
Hirtz J, Boesen M, Braun N, Deitmer JW, Kramer F, Lohr C, Müller B, Nothwang HG, Striessnig J, Löhrke S & Friauf E (2011): Cav1.3 calcium channels are required for normal development of the auditory brainstem. J. Neurosci. 31:8280-8294.
Lohr C, Thyssen A, Hirnet D (2011): Extrasynaptic neuron-glia communication: The how and why. Comm. Integr. Biol. 4:109-111.
2010
Thyssen A*, Hirnet D*, Wolburg H, Schmalzing G, Deitmer JW, Lohr C (2010): Ectopic vesicular neurotransmitter release along sensory axons mediates neurovascular coupling via glial calcium signaling. Proc. Natl. Acad. Sci. USA 107:15258-15263. (*equal contribution).
2009
Doengi M, Hirnet D, Coulon P, Pape HC, Deitmer JW, Lohr C (2009): GABA uptake-dependent Ca2+ signaling in olfactory bulb astrocytes. Proc. Natl. Acad. Sci. USA 106:17570-17575.
Lohr C, Deitmer JW (2009): Ca2+ imaging in glia. In: A. Verkhratsky and O. Petersen: Calcium measurement methods. Neuromethods 43:221-249.
Barros LF, Courjaret R, Jakoby P, Loaiza A, Lohr C, Deitmer JW (2009): Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: a multiphoton study of cerebellar slices. GLIA 57:962-970.
2008
Doengi M, Deitmer JW, Lohr C (2008): New evidence for purinergic signaling in the olfactory bulb: A2A and P2Y1 receptors mediate intracellular calcium release in astrocytes. FASEB J. 22, 2368-2378.
Stumpf T, Zhang Q, Hirnet D, Lewandrowski U, Sickmann A, Wissenbach U, Niedner-Schatteburg G, Lohr C, Deitmer JW, Fecher-Trost C (2008): The human TRPV6 channel protein is associated with cyclophilin B in human placenta. J. Biol. Chem. 283, 18086-18098.
Singaravelu K, Lohr C, Deitmer JW (2008): Calcium-independent phospholipase A2 mediates store-operated calcium entry in rat cerebellar granule cells in situ. Cerebellum 7, 467-481.
Deitmer JW, Singaravelu K, Lohr C (2008): Calcium signaling in astrocytes. In: V. Papura & PG Haydon: Astrocytes in (patho)physiology of the nervous system. Springer, Berlin Heidelberg New York, pp 201-224.
2007
Heil JE, Oland LA, Lohr C (2007): Acetylcholine-mediated axon-glia signaling in the developing insect olfactory system. Eur. J. Neurosci. 26, 1227-1241.
Rieger A, Deitmer JW, Lohr C (2007): Axon-glia communication evokes calcium signaling in olfactory ensheathing cells of the developing olfactory bulb. GLIA 55, 352-359.
Hartl S, Heil JE, Hirsekorn A, Lohr C (2007): A novel neurotransmitter-independent communication pathway between axons and glial cells. Eur. J. Neurosci. 25, 945-956.
Lohr C, Bergstein S, Hirnet, D (2007): Developmental distribution of CaM kinase II in the antennal lobe of the sphinx moth Manduca sexta. Cell Tiss. Res. 327, 189-197.
2006
Singaravelu K*, Lohr C*, Deitmer JW (2006): Regulation of store-operated calcium entry by calcium-independent phospholipase A2 in rat cerebellar astrocytes. J. Neurosci. 26, 9579-9592. (*equal contribution).
Lohr C, Deitmer JW (2006): Calcium signaling in invertebrate glial cells. GLIA 54, 642-649.
Wormit A, Trentmann O, Feifer I, Lohr C, Tjaden J, Meyer S, Schmidt U, Martinoia E, Neuhaus HE (2006): Molecular identification and physiological characterization of a novel monosaccharide transporter from Arabidopsis involved in vacuolar sugar transport. Plant Cell 18, 3476-3490.
2005
Lohr C, Heil JE, Deitmer JW (2005): Blockage of voltage-gated calcium signaling impairs migration of glial cells in vivo. GLIA 50, 198-211.
Callapina M, Zhou J, Schmid T, Schnitzer S, Lohr C, Deitmer JW & Brüne B (2005): Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1a accumulation – implications for prolyl hydroxylase activity and iron. Exp. Cell Res. 306, 274-284.
2003
Lohr C (2003): Monitoring neuronal calcium signalling using a new method for ratiometric confocal calcium imaging. Cell Calcium 34, 295-303.
2002
Lohr C, Tucker E, Oland LA, Tolbert LP (2002): Development of depolarization-induced calcium transients in insect glial cells is dependent on the presence of afferent axons. J. Neurobiol. 52, 85-98.
Beck A, Lohr C, Berthold H, Deitmer JW (2002): Dendritic calcium influx evoked by 5-hydroxytryptamine in the leech Retzius neuron. Cell Calcium 31, 137-149.
Britz FC, Lohr C, Schmidt J, Deitmer JW (2002): Characterization of a synaptiform transmission between an identified neuron and glial cell in the leech central nervous system. GLIA 38, 215-227.
2001
Lohr C, Oland LA, Tolbert LP (2001): Olfactory receptor axons influence the development of glial potassium currents in the antennal lobe of the moth Manduca sexta. GLIA 36, 309-320.
Beck A, Lohr C, Deitmer JW (2001): Action potential-induced calcium transients in different subcompartments of the leech Retzius neuron. J. Neurobiol. 48, 1-18.
Lohr C, Beck A, Deitmer JW (2001): Activity-dependent accumulation of Ca2+ in axon and dendrites of the leech Leydig neuron. NeuroReport 12, 3649-3653.
Deitmer JW, Lohr C, Britz FC, Schmidt J (2001): Glial signalling in response to neuronal activity in the leech central nervous system. Prog. Brain Res. 132, 225-236.
Beck A, Lohr C, Nett W, Deitmer JW (2001): Bursting activity in leech Retzius neurons induced by low external chloride. Pflügers Arch. Eur. J. Physiol. 442, 263-272.
1999
Lohr C, Deitmer JW (1999): Dendritic calcium transients in the leech giant glial cell in situ. GLIA 26, 109-118.
Deitmer JW, Rose CR, Munsch T, Schmidt J, Nett W, Schneider HP & Lohr C (1999): The leech giant glial cell: Its functional role in a simple nervous system. GLIA 28, 175-182.
1998
Deitmer JW, Verkhratsky A & Lohr C (1998): Calcium signalling in glial cells. Cell Calcium 24, 405-416.
1997
Lohr C & Deitmer JW (1997): Structural and physiological properties of leech giant glial cells as studied by confocal microscopy. Exp. Biol. Online 2:8.
Lohr C & Deitmer JW (1997): Intracellular Ca2+ release mediated by metabotropic glutamate receptor activation in the leech giant glial cell. J. exp. Biol. 200, 2565-2573.
1996
Lohr C, Rose CR & Deitmer JW (1996): Extracellular Ca2+ changes during transmitter application in the leech central nervous system. Neurosci. Lett. 205, 57-60.
1995
Rose CR, Lohr C & Deitmer JW (1995): Activity-induced Ca2+ transients in nerve and glial cells of the leech central nervous system. NeuroReport 6, 642-644.