Juliane Schulte

@article{de13b2762c9d4cd5a8a2d6919aa0c148,

title = "“Genotoxicity of Particles From Grinded Plastic Items in Caco2 and HepG2 Cells”",

abstract = "Large plastic litters degrade in the environment to micro- and nanoplastics, which maythen enter the food chain and lead to human exposure by ingestion. The present studyexplored ways to obtain nanoplastic particles from real-life food containers. The first set ofexperiments gave rise to polypropylene nanoplastic suspensions with a hydrodynamicparticle size range between 100 and 600 nm, whereas the same grinding process ofpolyethylene terephthalate (PET) produced suspensions of particles with a primary sizebetween 100 and 300 nm. The exposure did not cause cytotoxicity measured by thelactate dehydrogenase (LDH) and water soluble tetrazolium 1 (WST-1) assays in Caco-2and HepG2 cells. Nanoplastics of transparent PET food containers produced a modestconcentration-dependent increase in DNA strand breaks, measured by the alkalinecomet assay [net induction of 0.28 lesions/106 bp at the highest concentration (95%CI: 0.04; 0.51 lesions/106 base pair)]. The exposure to nanoplastics from transparentpolypropylene food containers was also positively associated with DNA strand breaks[i.e., net induction of 0.10 lesions/106 base pair (95% CI: −0.04; 0.23 lesions/106 basepair)] at the highest concentration. Nanoplastics from grinding of black colored PET foodcontainers demonstrated no effect on HepG2 and Caco-2 cells in terms of cytotoxicity,reactive oxygen species production or changes in cell cycle distribution. The net inductionof DNA strand breaks was 0.43 lesions/106 bp (95% CI: 0.09; 0.78 lesions/106 bp) atthe highest concentration of nanoplastics from black PET food containers. Collectively,the results indicate that exposure to nanoplastics from real-life consumer products cancause genotoxicity in cell cultures.",

keywords = "DNA damage, comet assay, microplastic, nanoparticles, oxidative stress",

author = "Martin Roursgaard and {Hezareh Rothmann}, Monika and Juliane Schulte and Ioanna Karadimou and Elena Marinelli and Peter M{\o}ller",

year = "2022",

month = jul,

day = "6",

doi = "10.3389/fpubh.2022.906430",

language = "English",

volume = "10",

journal = "Frontiers in Public Health",

issn = "2296-2565",

publisher = "Frontiers Media S. A.",

@article{d467a757274c444c8c2a73799ba11b0f,

title = "“A brief perspective on environmental science in the Anthropocene: Recalibrating, rethinking and re-evaluating to meet the challenge of complexity”",

abstract = "A convincing case has been made that the scale of human activity has reached such pervasiveness that humans are akin to a force of nature. How environmental science responds to the many new challenges of the Anthropocene is at the forefront of the field. The aim of this perspective is to describe Anthropocene as a concept and a time period and discuss its relevance to the contemporary study of environmental science. Specifically, we consider areas in environmental science which may need to be revisited to adjust to complexity of the new era: (a) recalibrate the idea of environmental baselines as Anthropogenic baselines; (b) rethink multiple stressor approaches to recognize a system under flux; (c) re-evaluate the relationship of environmental science with other disciplines, particularly Earth Systems Science, but also social sciences and humanities. The all-encompassing nature of the Anthropocene necessitates the need to revise and reorganize to meet the challenge of complexity.",

keywords = "An-thropocene baselines, Earth system science, Ecosystem health, Environmental science, Multiple stressors",

author = "Farhan Khan and {Storebjerg Croft}, Stephanie and {Escabia Herrando}, Elisa and Athanasios Kandylas and Tabea Meyerjuergens and Dylan Rayner and Juliane Schulte and {Valdemarson {\'a} L{\o}gmansb{\o}}, Ingmar",

year = "2021",

month = sep,

day = "23",

doi = "10.3390/environments8100098",

language = "English",

volume = "8",

journal = "MDPI Environments",

issn = "2076-3298",

publisher = "MDPI",

number = "10",