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Links to Databases for Molecular Biologists
 
Global Sequence Databases
International Nucleotide Sequence Database Collaboration:
  DNA Data Bank of Japan (DDBJ)   http://www.ddbj.nig.ac.jp   All known nucleotide and protein sequences
  EMBL Nucleotide Sequence Database   http://www.ebi.ac.uk/embl/   All known nucleotide and protein sequences
  GenBank   http://www.ncbi.nlm.nih.gov/   All known nucleotide and protein sequences
Non-redundant, gene-oriented clusters:
  NCBI Reference Sequence Project   http://www.ncbi.nlm.nih.gov./RefSeq/   Naturally-occuring biological molecules
  H-InvDB   http://www.jbirc.aist.go.jp/hinv/index.jsp   Human gene database, with Integrative Annotation Validated by Full-Length cDNA Clones
  STACK   http://www.sanbi.ac.za/Dbases.html   Sequences expressed in the human genome
  TIGR Gene Indices   http://www.tigr.org/tdb/index.shtml   Microbes, plants and humans
  UniGene   http://www.ncbi.nlm.nih.gov/UniGene/   GenBank sequences partitioned into a non-redundant set
  Ensembl   http://www.ensembl.org   Annotated information on eukaryotic genomes
  UCSC Genome Browser   http://genome.ucsc.edu/   Genome assemblies and annotation
Comparative Genomics
  Clusters of Orthologous Groups (COG)   http://www.ncbi.nlm.nih.gov/COG/   Phylogenetic classification of proteins from 43 complete genomes
  CORG   http://corg.molgen.mpg.de   Conserved non-coding sequence blocks
  Homophila   http://homophila.sdsc.edu   Relationship of human disease genes to genes in Drosophila
  MBGD   http://mbgd.genome.ad.jp   Microbial genome database for comparative genomic analysis
  ParaDB   http://abi.marseille.inserm.fr/paradb   Paralogy mapping in human genomes
  XREFdb   http://www.ncbi.nlm.nih.gov/XREFdb/   Cross-referencing of model organism genetics with mammalian phenotypes
Gene Expression
  ArrayExpress   http://www.ebi.ac.uk.arrayexpress   Public collection of microarray gene expression data
  ASDB   http://cbcg.nersc.gov/asdb   Protein products and expression patterns of alternatively-spliced genes
  Axeldb   http://www.dkfz-heidelberg.de/
abt0135/axeldb.htm
  Gene expression in Xenopus
  BodyMap   http://bodymap.ims.u-tokyo.ac.jp/   Human and mouse gene expression data
  EPConDB   http://www.cbil.upenn.edu/EPConDB   Endocrine pancreas consortium database
  EpoDB   http://www.cbil.upenn.edu/EpoDB/index.html   Genes expressed in vertebrate red blood cells
  FlyView   http://pbio07.uni-muenster.de/   Drosophila development and genetics
  Gene Expression Database (GXD)   http://www.informatics.jax.org/
searches/gxdindex_form.shtml
  Mouse gene expression and genomics
  HugeIndex   http://hugeindex.org   mRNA expression levels of human genes in normal tissues
  Interferon Stimulated Gene Database   http://www.lerner.ccf.org/
labs/williams/xchip-html.cgi
  Genes induced by treatment with interferons
  Kidney Development Database   http://golgi.ana.ed.ac.uk/kidhome.html   Kidney development and gene expression
  MAGEST   http://www.genome.ad.jp/magest/   Maboya ( the ascidian, Halocynthia roretzi ) Gene Expression patterns and Sequence Tags
  MEPD   http://medaka.dsp.jst.go.jp/MEPD   Gene expression data from the small freshwater fish Medaka
  MethDB   http://www.methdb.de   DNA methylation data, patterns, and profiles
  MIRAGE   http://www.ifti.org/   Molecular informatics resource for the analysis of gene expression
  Mouse Atlas and Gene Expression Database   http://genex.hgu.mrc.ac.uk   Spatially-mapped gene expression data
  MTID   http://mouse.ccgb.umn.edu/transposon/   Sleeping beauty transposon insertion in mice
  NetAffix   http://www.affymetrics.com   Public Affymetrix probesets and annotations
  PEDB   http://www.pedb.org/   Normal and aberrant prostate gene expression
  RECODE   http://recode.genetics.utah.edu   Genes using programmed translational recoding in their expression
  SeedGenes   http://www.seedgenes.org   Genes essential for Arabidopsis development
  Stanford Microarray Database   http://genome-www.stanford.edu/microarray   Raw and normalized data from microarray experiments
  Tooth Development Database   http://bite-it.helsinki.fi/   Gene expression in dental tissue
  TRANSPATH   http://www.biobase.de/pages/
products/databases.html
  Gene regulatory networks and microarray analysis
  TRIPLES   http://ygac.med.yale.edu/triples/triples.htm   TRansposon-Insertion Phenotypes, Localization, and Expression in Saccharomyces
Gene Identification and Structure
  AllGenes   http://www.allgenes.org   Human and mouse gene index integrating gene, transcript and protein annotation
  Ares Lab Intron Site   http://www.cse.ucsc.edu/research/
compbio/yeast_introns.html
  Yeast spliceosomal introns
  ASAP   http://www.bioinformatics.ucla.edu/ASAP   Alternative spliced isoforms
  COMPEL   http://compel.bionet.nsc.ru/   Database on composite regulatory elements affecting gene transcription in eukaryotes
  CUTG   http://www.kazusa.or.jp/codon/   Codon usage tables
  DBTBS   http://elmo.ims.u-tokyo.ac.jp/dbtbs/   Bacillus subtilis promoters and transcription factors
  EID   http://mcb.harvard.edu/gilbert/EID/   Protein-coding, intron-containing genes
  EPD   http://www.epd.isb-sib.ch/   Eukaryotic POL II promoters with experimentally-determined transcription start sites
  ExInt   http://intron.bic.nus.edu.sg/exint/exint.html   Exon-intron structure of eukaryotic genes
  Gene Resource Locator   http://grl.gi.u-tokyo.ac.jp   Alignment of ESTs with finished human sequence
  HS3D   http://www.sci.unisannio.it/docenti/rampone/   Human exon, intron and splice regions
  HUNT   http://www.hri.co.jp/HUNT   Annotated human full-length cDNA sequences
  HvrBase   http://www.hvrbase.org   Primate mtDNA control region sequences
  IDB/IEDB   http://nutmeg.bio.indiana.edu/intron/index.html   Intron sequence and evolution
  MICdb   http://www.cdfd.org.in/micas   Prokaryotic microsattelites
  PACRAT   http://www.biosci.ohio-state.edu/~pacrat   Archaeal and bacterial intergenic sequence features
  PLACE   http://www.dna.affrc.go.jp/htdocs/PLACE   Plant cis-acting regulatory elements
  PlantCARE   http://oberon.rug.ac.be:8080/PlantCARE/index.html   Plant transcription sites
  PlantProm   http://mendel.cs.rhul.ac.uk/   Proximal promoter sequences for RNA polymerase II
  PromEC   http://bioinfo.md.huji.ac.il/marg/promec   E. coli mRNA promoters with experimentally identified transcriptional start sites
  RRNDB   http://rrndb.cme.msu.edu   Variation in prokaryotic ribosomal RNA operons
  rSNP Guide   http://wwwmgs.bionet.nsc.ru/mgs/systems/rsnp/   Single nucleotide polymorphisms in regulatory gene regions
  RTPrimerDB   http://www.realtimeprimerdatabase.ht.st/   Validated PCR primer and probe sequence records
  SNP Consortium database   http://snp.cshl.org   Single Nucleotide Polymorphisms for biomedical research
  Sputnik   http://mips.gsf.de/proj/sputnik   Functional annotation of clustered plant ESTs
  STRBase   http://www.cstl.nist.gov/div831/strbase/   Short tandem DNA repeats
  TRANSCompel   http://www.gene-regulation.com/pub/
databases.html#transcompel
  Composite regulatory elements
  TransTerm   http://uther.otago.ac.nz/Transterm.html   Codon usage, start and stop signals
  TRRD   http://wwwmgs.bionet.nsc.ru/mgs/dbases/trrd4/   Transcription regulatory regions of eukaryotic genes
  VIDA   http://www.biochem.ucl.ac.uk/
bsm/virus_database/VIDA.html
  Virus genome open reading frames
  WormBase   http://www.wormbase.org   Guide to C. elegans biology
Genetic and Physical Maps
  DRESH   http://www.tigem.it/LOCAL/drosophila/dros.html   Human cDNA clones homologous to Drosophila mutant genes
  G3-RH   http://www-shgc.stanford.edu/RH/   Stanford G3 and TNG radiation hybrid maps
  GB4-RH   http://www.sanger.ac.uk/
Software/RHserver//RHserver.shtml
  Genebridge4 (GB4) human radiation hybrid maps
  GDB   http://www.gdb.org   Human genes and genomic maps
  GenAtlas   http://www.dsi.univ-paris5.fr/genatlas/   Human genes, markers, and phenotypes
  GeneLoc   http://genecards.weizmann.ac.il/udb/   Integrated human maps
  GeneMap '99   http://www.ncbi.nlm.nih.gov/genemap/   International Radiation Mapping Consortium human gene map
  Genetpig   http://www.infobiogen.fr/services/Genetpig   Genetic mapping in pig
  GenMapDB   http://genomics.med.upenn.edu/genmapdb   Mapped human BAC clones
  HuGeMap   http://www.infobiogen.fr/services/Hugemap   Human genome genetic and physical map data
  IXDB   http://ixdb.mpimg-berlin-dahlem.mpg.de   Physical maps of human chromosome X
  RHdb   http://www.ebi.ac.uk/RHdb   Radiation hybrid map data
Genomic Databases
  ACeDB   http://www.sanger.ac.uk/Software/Acedb/   C. elegans, S. pombe, and human sequences and genomic information
  AMmtDB   http://bighost.area.ba.cnr.it/mitochondriome   Metazoan mitochondrial genes
  ArkDB   http://www.thearkdb.org/species.html   Genome databases for farm and other animals
  ASAP   https://asap.ahabs.wisc.edu/annotation/ASAP1.htm   Systematic annotation package for community-based annotation and analysis of genomes
  BSD   http://bsd.cme.msu.edu   Comparative data on known biodegradative organisms
  CATMA   http://www.catma.org   Arabidopsis gene sequence tags (GSTs)
  CnidBase   http://cnidbase.bu.edu/   Cnidarian evolutionary genomics and gene expression
  Comprehensive Microbial Resource   http://www.tigr.org/
tigr-scripts/CMR2/CMRHomePage.spl
  Completed microbial genomes
  CropNet   http://ukcrop.net/   Genome mapping in crop plants
  CroW 21   http://bioinfo.weizmann.ac.il/crow21/   Human chromosome 21 database
  CyanoBase   http://www.kazusa.or.jp/cyano/   Synechocystis sp. genome
  EcoGene   http://bmb.med.miami.edu/EcoGene/EcoWeb/   E. coli K-12 sequences
  EMGlib   http://pbil.univ-lyon1.fr/emglib/emglib.html   Completely sequenced microbial genomes from bacteria, archaea, yeast
  ERGO   http://ergo.integratedgenomics.com/ERGO   Integrated biological data from genomic, biochemical, expression, and genetic experiments, and from the literature
  FlyBase   http://www.fruitfly.org   Drosophila sequences and genomic information
  Full-Malaria   http://fullmal.ims.u-tokyo.ac.jp   Full-length cDNA library from erythrocytic-stage Plasmodium falciparum
  GeneCards   http://bioinfo.weizmann.ac.il/cards   Integrated database of human genes, maps, proteins and diseases
  Genew   http://www.gene.ucl.ac.uk./cgi-bin/
nomenclature/searchgenes.pl
  Approved symbols for all human genes
  GOBASE   http://megasun.bch.umontreal.ca/
gobase/gobase.html
  Organelle genome database
  GOLD   http://igweb.integratedgenomics.com/GOLD/   Information regarding complete and ongoing genome projects
  GénoPlante-Info   http://genoplante-info.infobiogen.fr   Plant genomic data derived from the Génoplante consortium
  GrainGenes   http://www.graingenes.org   Genomic database for small-grain crops
  HGT-DB   http://www.fut.es/~debb/HGT/   Putative horizontally-transferred genes in prokaryotic genomes
  HIV Sequence Database   http://hiv-web.lanl.gov/   HIV RNA sequences
  HOWDY   http://www-alias.tokyo.jst.go.jp/HOWDY/   Integrated human genomic information
  Human BAC Ends Database   http://www.tigr.org/tdb/humgen/
bac_end_search/bac_end_intro.html
  Non-redundant human BAC end sequences
  ICB   http://www.mbio.co.jp/icb   Identification and classification of bacteria using protein-coding
  INE   http://rgp.dna.affrc.go.jp/giot/INE.html   Rice genetic and physical maps and sequence data
  IRIS   http://www.iris.irri.org   Rice germplasm geneology and field data; rice structural and functional genomics and proteomics
  Medicago Genome Initiative   http://www.noble.org/medicago/   Model legume Medicago truncatula ESTs, gene expression, and proteomic data
  Mendel Database   http://www.mendel.ac.uk/   Database of plant EST and STS sequences annotated with gene family information
  MIPS   http://www.mips.biochem.mpg.de/   Protein and genomic sequences
  MitoDat   http://www-lecb.ncifcrf.gov/mitoDat/   Mitochondrial proteins (predominantly human)
  MITOMAP   http://www.mitomap.org   Human mitochondrial genome
  MitoNuc/MitoAln   http://bighost.area.ba.cnr.it/srs/   Nuclear genes coding for mitochondrial proteins
  MITOP   http://mips.gsf.de/proj/medgen/mitop/   Mitochondrial proteins, genes, and diseases
  MOsDB   http://mips.gsf.de/proj/rice   Oryza sativa genome
  Mouse Genome Database (MGD)   http://www.informatics.jax.org   Mouse genetics and genomics
  MtDB   http://www.medicago.org/MtDB   Medicago trunculata genome
  Munich Information Center for Protein Sequences (MIPS)   http://www.mips.biochem.mpg.de/   Protein and genomic sequences
  NRSub   http://pbil.univ-lyon1.fr/nrsub/nrsub.html   Bacillus subtilis genome
  OGRe   http://www.bioinf.man.ac.uk/ogre   Complete mitochondrial genome sequences for 200 metazoan species
  Oryzabase   http://www.shigen.nig.ac.jp/rice/oryzabase   Rice genetics and genomics
  PEDANT genome database   http://pedant.gsf.de   Automated analysis of genomic sequences
  Phytophora Genome Consortium Database   http://xgi.ncgr.org/pgc   ESTs from Phytophthora infestans and Phytophthora sojae
  PlantGDB   http://zmdb.iastate.edu/PlantGDB/   Actively-transcribed plant genomic sequences
  PlasmoDB   http://PlasmoDB.org   The Plasmodium falciparum Genome Database
  Proteome BioKnowledge Library   http://www.proteome.com   Model organism pathogen, and mammalian proteomes
  Rat Genome Database   http://rgd.mcw.edu   Rat genetic and genomic data
  Rice GAAS   http://RiceGaas.dna.affrc.go.jp/   Rice genome sequence
  RsGDB   http://mmg.uth.tmc.edu/sphaeroides   Rhodobacter sphaeroides genome
  RTPrimerDB   http://www.realtimeprimerdatabase.ht.st/   Validated PCR primer and probe sequence records
  Saccharomyces Genome Database (SGD)   http://genome-www.stanford.edu/Saccharomyces   Saccharomyces cerevisiae genome
  SOURCE   http://source.stanford.edu   Functional genomic resource for annotations ontologies, and expression data
  SubtiList   http://genolist.pasteur.fr/SubtiList   Bacillus subtilis genome
  The Arabidopsis Information Resource (TAIR)   http://www.arabidopsis.org   Arabidopsis thaliana genome
  TIGR Microbial Database   http://www.tigr.org/tdb/mdb/mdbcomplete.html   Microbial genomes and chromosomes
  TIGR Rice Genome Annotation Resource   http://www.tigr.org/tdb/e2k1/osa1/   Rice sequence, BAC/PAC clones and related mapping data
  ToxoDB: The Toxoplasma gondii Genome Database   http://ToxoDB.org   Apicomplexan parasite Toxoplasma gondii genome
  WILMA   http://lore.came.sbg.ac.at:8080/
CAME/CAME_EXTERN/WILMA/
  Caenorhabditis elegans annotation
  WorfDB   http://worf.dfci.harvard.edu   Caenorhabditis elegans ORFeome
  WormBase   http://www.wormbase.org   Genomic data on C. elegans and related nematodes
  ZFIN   http://www.zfin.org   Genetic, genomic and developmental data from zebrafish
  ZmDB   http://zmdb.iastate.edu/   Maize genome database
Intermolecular Interactions
  Biomolecular Interaction Network Database (BIND)   http://binddb.org   Molecular interactions, complexes, and pathways
  DIP   http://dip.doe-mbi.ucla.edu/   Catalog of protein-protein interactions
  Database of Ribosomal Crosslinks (DRC)   http://www.mpimg-berlin-dahlem.mpg.de/
~ag_ribo/ag_brimacombe/drc/
  Ribosomal crosslinking data
  DPInteract   http://arep.med.harvard.edu/dpinteract/   Binding sites for E. coli DNA-binding proteins
  InterDom   http://InterDom.lit.org.sg   Putative protein domain interactions
  JenPep   http://www.jenner.ac.uk/Jenpep2   Functional and quantitative thermodynamic data on peptide binding to immunological biomacromolecules
  KDBI   http://xin.cz3.nus.edu.sg/group/kdbi/kdbi.asp   Kintic data on biomolecular interactions
  MHC-Peptide Interaction Database   http://surya.bic.nus.edu.sg/mpid   Class I and class II MHC-peptide complexes
  STRING   http://www.bork.embl-heidelberg.de/STRING/   Predicted functional associations between proteins
Metabolic Pathways and Cellular Regulation
  EcoCyc   http://ecocyc.org/   E. coli K-12 genome, gene products, and metabolic pathways
  ENZYME   http://www.expasy.ch/enzyme/   Enzyme nomenclature
  EpoDB   http://www.cbil.upenn.edu/EpoDB/   Genes expressed during human erythropoiesis
  Klotho   http://www.biocheminfo.org/klotho   Collection and categorization of biological compounds
  Kyoto Encyclopedia of Genes and Genomes (KEGG)   http://www.genome.ad.jp/kegg/   Metabolic and regulatory pathways
  LIGAND   http://www.genome.ad.jp/dbget/ligand.html   Enzymatic ligands, substrates, and reactions
  MetaCyc   http://ecocyc.org   Metabolic pathways and enzymes from various organisms
  The University of Minnesota Biocatalysis Biodegradation Database   http://umbbd.ahc.umn.edu/   Curated information on microbial catabolism and related biotransformations
  PathDB   http://www.ncgr.org/pathdb   Biochemical pathways, compounds and metabolism
  PRODORIC   http://prodoric.tu-bs.de   Prokaryotic database of gene regulation and regulatory networks
  RegulonDB   http://www.cifn.unam.mx/
Computational_Genomics/regulondb/
  E. coli transcriptional regulation and operon organization
  UM-BBD   http://www.labmed.umn.edu/umbbd/   Microbial biocatalytic reactions and biodegradation pathways
  WIT2   http://wit.mcs.anl.gov/WIT2/   Integrated system for functional curation and development of metabolic models
Mutation Databases
  ALFRED   http://alfred.med.yale.edu/
alfred/index.asp
  Allele frequencies and DNA polymorphisms
  Androgen Receptor Gene Mutations Database   http://www.mcgill.ca/androgendb/   Mutations in the androgen receptor gene
  Asthma Gene Database   http://cooke.gsf.de/asthmagen/main.cfm   Linkage and mutation studies on the genetics of asthma and allergy
  Atlas of Genetics and Cytogenetics in Oncology and Haematology   http://www.infobiogen.fr/
services/chromcancer/
  Chromosomal abnormalities in cancer
  BTKbase   http://bioinf.uta.fi/BTKbase/   Mutation registry for X-linked agammaglobulinemia
  CASRDB   http://www.casrdb.mcgill.ca/   Calcium Sensing Receptor Locus Mutation Database
  Cytokine Gene Polymorphism Database   http://www.bris.ac.uk/pathandmicro/
services/GAI/cytokine4.htm
  Cytokine gene polymorphisms, in vitro expression and disease-association studies
  Database of Germline p53 Mutations   http://www.lf2.cuni.cz/
win/projects/germline_mut_p53.htm
  Mutations in human tumor and cell line p53 gene
  dbSNP   http://www.ncbi.nlm.nih.gov/SNP/   Single nucleotidepolymorphisms
  FLAGdb/FST   http://genoplante-info.infobiogen.fr   Arabidopsis thaliana T-DNA transformants
  GRAP Mutant Databases   http://tinyGRAP.uit.no/GRAP/   Mutants of family A G-Protein Coupled Receptors (GRAP)
  Haemophila B Mutation Database   http://www.kcl.ac.uk/ip/
petergreen/haemBdatabase.html
  Point mutations, short additions, and deletions in the Factor IX gene
  HGVbase   http://hgvbase.cgb.ki.se/   Human Genome Variation database
  HIV-RT   http://hivdb.stanford.edu/hiv/   HIV reverse transcriptase and protease sequence variation
  Human Gene Mutation Database (HGMD)   http://www.hgmd.org   Known (published) gene lesions underlying human inherited disease
  Human p53/hprt, rodent lacI/lacZ databases   http://www.ibiblio.org/dnam/mainpage.html   Mutationsat the human p53 and hprt genes; rodent transgenic lacI and lacZ mutations
  Human PAX2 Allelic Variant Database   http://www.hgu.mrc.ac.uk/Softdata/PAX2/   Mutations in human PAX2 gene
  Human PAX6 Allelic Variant Database   http://www.hgu.mrc.ac.uk/Softdata/PAX6/   Mutations in human PAX6 gene
  Human Type I and Type III Collagen Mutation Database   http://www.le.ac.uk/genetics/collagen/   Human type I and type III collagen gene mutations
  HvrBase   http://www.hvrbase.de   Primate mtDNA control region sequences
  iARC p53 Database   http://www.iarc.fr/p53/   Missense mutations and small deletions in human p53 reported in peer-reviewed literature
  KinMutBase   http://bioinf.uta.fi/KinMutBase/   Disease-causing protein kinase mutations
  Mutation Spectra Database   http://info.med.yale.edu/mutbase/   Mutations in viral, bacterial, yeast, and mammalian genes
  NCL Mutations   http://www.ucl.ac.uk/ncl/   Mutations and polymorphisms in neuronal ceroid lipofuscinoses (NCL) genes
  Online Mendelian Inheritance in Animals   http://www.angis.org.au/omia   Catalog of animal genetic and genomic disorders
  Online Mendelian Inheritance in Man   http://www.ncbi.nlm.nih.gov/Omim/   Catalog of human genetic and genomic disorders
  p53 Databases   http://metalab.unc.edu/dnam/mainpage.html   Mutations at the human p53 and hprt genes; rodent transgenic lacI and lacZ mutations
  PAHdb   http://www.pahdb.mcgill.ca/   Mutations at the phenylalanine hydroxylase locus
  PHEXdb   http://www.phexdb.mcgill.ca/   Mutations in PHEX gene causing X-linked hypophosphatemia
  PMD   http://pmd.ddbj.nig.ac.jp/   Compilation of protein mutant data
  PTCH Mutation Database   http://www.cybergene.se/PTCH/ptchbase.html   Mutations and SNPs found in PTCH1
  RB1 Gene Mutation Database   http://www.d-lohmann.de/Rb/   Mutations in the human retinoblastoma (RB1) gene
  SV40 Large T-Antigen Mutant Database   http://colon.bio.pitt.edu:5243/SV40/index.html   Mutations in SV40 large tumor antigen gene
Pathology
  BayGenomics   http://www.ncbi.nlm.nih.gov/Omim/   Catalog of human genetic and genomic disorders
  FIMM   http://baygenomics.ucsf.edu   Identification of genes relevant to cardiovascular and pulmonary disease
  GOLD.db   http://gold.tugraz.at   Genes, proteins, and pathways implicated in lipid-associated disorders
  INFEVERS   http://fmf.igh.cnrs.fr/infevers   Familial Mediterranean Fever and hereditary inflammatory disorder mutation data
  MetaFMF   http://fmf.igh.cnrs.fr/metaFMF/index_us.html   Familial Mediterranean Fever phenotype-genotype correlation
  Mouse Tumor Biology Database (MTB)   http://tumor.informatics.jax.org   Mouse tumor names, classification, incidence, pathology, genetic factors
  Oral Cancer Gene Database   http://www.tumor-gene.org/Oral/oral.html   Cellular, molecular, and biological data for genes involved in oral cancer
  PEDB   http://www.pedb.org/   Sequences from prostate tissue and cell type-specific cDNA libraries
  PGDB   http://www.ucsf.edu/pgdb/index.htm   Genes and genomic loci related to the prostate and prostatic diseases
  Tumor Gene Family Databases (TGDBs)   http://www.tumor-gene.org/tgdf.html   Cellular, molecular, and biological data about genes involved in various cancers
Protein Databases
  AARSDB   http://rose.man.poznan.pl/aars/index.html   Aminoacyl-tRNA synthetase sequences
  ABCdb   http://ir2lcb.cnrs-mrs.fr/ABCdb/   ABC transporters
  AraC/XylS database   http://www.AraC-XylS.org   AraC/XylS protein family of positive regulators in bacteria
  ASPD   http://wwwmgs.bionet.nsc.ru/mgs/gnw/aspd/   Artificial selected proteins/peptides database
  CSDBase   http://www.chemie.uni-marburg.de/~csdbase   Cold shock domain-containing proteins
  DAtA   http://luggagefast.Stanford.EDU/
group/arabprotein/
  Annotated coding sequences from Arabidopsis
  DExH/D Family Database   http://www.helicase.net/dexhd/dbhome.htm   DEAD-box, DEAH-box, and DExH-box proteins
  Endogenous GPCR List   http://www.biomedcomp.com/GPCR.html   G protein-coupled receptors; expression in cell lines
  ESTHER   http://bioweb.ensam.inra.fr/ESTHER/
general?what=index
  Esterases and alpha/beta hydrolase enzymes and relatives
  EXProt   http://www.cmbi.nl/exprot   Proteins with experimentally-verified function
  FUNPEP   http://www.cmbi.kun.nl/swift/FUNPEP/library/   Low-complexity or compositionally-biased protein sequences
  GenProtEC   http://genprotec.mbl.edu   Escherichia coli K-12 genome, gene products, and homologs
  GPCRDB   http://www.gpcr.org/7tm/   G protein-coupled receptors
  Histone Database   http://genome.nhgri.nih.gov/histones/   Histone and histone fold sequences and structures
  HIV Molecular Immunology Database   http://hiv-web.lanl.gov/immunology/   HIV epitopes
  HIV RT and Protease Sequence Database   http://hivdb.stanford.edu   HIV reverse transcriptase and protease sequences
  Homeobox Page   http://homeobox.biosci.ki.se   Information relevant to homeobox proteins, classification, and evolution
  Homeodomain Resource   http://genome.nhgri.nih.gov/homeodomain   Homeodomain sequences, structures, and related genetic and genomic information
  HORDE   http://bioinfo.weizmann.ac.il/HORDE/   Catalog of human genetic and genomic disorders
  HUGE   http://www.kazusa.or.jp/huge/   Large (50 kDa) human proteins and cDNA sequences
  IMGT   http://imgt.cines.fr:8104/   Immunoglobulin, T cell receptor, and MHC sequences from human and other vertebrates
  IMGT/HLA   http://www.ebi.ac.uk/imgt/hla/   Human major histocompatibility comples
  IMGT/MHC Database   http://www.ebi.ac.uk/imgt/mhc   Major histocompatibility complex sequences
  InBase   http://www.neb.com/neb/inteins.html   Intervening protein sequences (inteins) and motifs
  InterPro   http://www.ebi.ac.uk/interpro   Protein families and domains
  Kabat Database   http://immuno.bme.nwu.edu/   Sequences of proteins of immunological interest
  LGICdb   http://www.pasteur.fr/
recherche/banques/LGIC/LGIC.html
  Ligand-gated ion channel subunit sequences
  Lipase Engineering Database   http://www.led.uni-stuttgart.de/   Integrated information on sequence, structure and function of lipases and esterases
  MEROPS   http://www.merops.co.uk   Proteolytic enzymes (proteases/peptidases)
  MetaFam   http://metafam.ahc.umn.edu/   Integrated protein family information
  Metalloprotein Database and Browser   http://metallo.scripps.edu/   Metal-binding sites in metalloproteins
  MHCPEP   http://wehih.wehi.edu.au/mhcpep/   MHC-binding peptides
  MitoDrome   http://bighost.area.ba.cnr.it/BIG/MitoDrome   Drosophila nuclear genes encoding proteins targeted to the mitochondrion
  MPIMP   http://millar3.biochem.uwa.edu.au/
~lister/index.html
  Mitochondrial protein import machinery of plants
  Nuclear Protein Database (NPD)   http://npd.hgu.mrc.ac.uk   Proteins localized in the nucleus
  NRMD   http://www.receptors.org/NR/   An Information System for Nuclear Receptors
  Nuclear Receptor Resource   http://nrr.georgetown.edu/nrr/nrr.html   Nuclear receptor superfamily
  NUREBASE   http://www.ens-lyon.fr/LBMC/
laudet/nurebase.html
  Nuclear Receptor dataBase
  Olfactory Receptor Database   http://senselab.med.yale.edu/senselab/   Sequences for olfactory receptor-like molecules
  ooTFD   http://www.ifti.org   Transcription factors and gene expression
  PANTHER   http://panther.celera.com   Gene products organized by biological function
  Peptaibol   http://www.cryst.bbk.ac.uk/
peptaibol/welcome.html
  Peptaibol (antibiotic peptide) sequences
  PhosphoBase   http://www.cbs.dtu.dk/
databases/PhosphoBase/
  Protein phosphorylation sites
  PIR-NREF   http://pir.georgetown.edu/pirwww/pirnref.shtml   Non-redundant reference database with comprehensive protein sequences
  PKR   http://pkr.sdsc.edu/html/index.shtml   Protein kinase sequences, enzymology, genetics, and molecular and structural properties
  PlantsP/PlantsT   http://plantsp.sdsc.edu   Functional genomics databases focusing on protein involved in plant phosphorylation and membrane transport
  PPMdb   http://sphinx.rug.ac.be:8080/
ppmdb/index.html
  Arabidopsis plasma membrane protein sequence and expression data
  Prolysis   http://delphi.phys.univ-tours.fr/Prolysis/   Proteases and natural and synthetic protease inhibitors
  PROMISE   http://metallo.scripps.edu/PROMISE/   Prosthetic centers and metal ions in protein active sites
  Protein Information Resource (PIR)   http://pir.georgetown.edu   Comprehensive, annotated, non-redundant protein sequence database
  ProtoNet   http://www.protonet.cs.huji.ac.il/   Hierarchical clustering of SWISS-PROT
  Ribonuclease P Database   http://www.mbio.ncsu.edu/RNaseP/home.html   RNase P sequences, alignments, and structures
  RTKdb   http://pbil.univ-lyon1.fr/RTKdb   Receptor tyrosine kinase sequences
  SDAP   http://fermi.utmb.edu/SDAP   Sequences, structures and IgE epitopes of allergenic proteins
  SENTRA   http://www-wit.mcs.anl.gov/sentra/   Sensory signal transduction proteins
  SEVENS   http://sevens.cbrc.jp   7-transmembrane helix receptors
  SRPDB   http://bio.lundberg.gu.se/dbs/
SRPDB/SRPDB.html
  Structural and functional information on signalrecognition particles
  SWISS-PROT/TrEMBL   http://www.expasy.ch/sprot   Curated protein sequences
  TIGRFAMs   http://www.tigr.org/TIGRFAMs   Protein family resource for the functional identification of proteins
  TRANSFAC   http://transfac.gbf.de/TRANSFAC/index.html   Transcription factors and binding sites
  trEST, trGEN and Hits   http://hits.isb-sib.ch   Predicted protein sequences
  VIDA   http://www.biochem.ucl.ac.uk/bsm/
virus_database/VIDA.html
  Homologous viral protein families
  Wnt Database   http://www.stanford.edu/
~rnusse/wntwindow.html
  Wnt secreted signaling molecules - proteins and phenotypes
Protein Sequence Motifs
  ASC-Active Sequence Collection   http://crisceb.unina2.it/ASC/   Biologically-active short amino acid sequences
  BLOCKS   http://blocks.fhcrc.org/   Conserved sequence regions of protein families
  CDD   http://www.ncbi.nlm.nih.gov/Structure/
cdd/cdd.shtml
  Alignment models for conserved protein domains
  CluSTr   http://www.ebi.ac.uk/clustr/   Automatic classification of SWISS-PROT + TrEMBL proteins into related groups
  eMOTIF   http://motif.stanford.edu/emotif   Protein sequence motif determination and searches
  InterPro   http://www.ebi.ac.uk/interpro/   Integrated documentation resource for protein families, domains, and sites
  iPROCLASS   pir.georgetown.edu/iproclass/   Annotated protein classification database
  NESbase   http://www.cbs.dtu.dk/databases/NESbase   Nuclear export signals
  NLSdb   http://cubic.bioc.columbia.edu/db/NLSdb   Nuclear localization signals
  O-GLYCBASE   http://www.cbs.dtu.dk/databases/OGLYCBASE/   Glycoproteins and O-linked glycosylation sites
  Pfam   http://www.sanger.ac.uk/Software/Pfam/   Multiple sequence alignments and hidden Markov models of common protein domains
  PIR-ALN   http://www-nbrf.georgetown.edu/
pirwww/dbinfo/piraln.html
  Protein sequence alignments
  PRINTS   http://www.bioinf.man.ac.uk/
dbbrowser/PRINTS/
  Hierarchical gene family fingerprints
  ProClass   http://pir.georgetown.edu/
gfserver/proclass.html
  Protein families defined by PIR superfamilies and PROSITE patterns
  ProDom   http://prodes.toulouse.inra.fr/prodom/
2002.1/html/home.php
  Protein domain families
  PROSITE   http://www.expasy.ch/prosite/   Biologically-significant protein patterns and profiles
  ProtoMap   http://protomap.cornell.edu   Automated hierarchical classification of SWISS-PROT proteins
  SBASE   http://www3.icgeb.trieste.it/~sbasesrv/   Annotated protein domain sequences
  SMART   http://smart.embl-heidelberg.de/   Signalling domain sequences
  SUPFAM   http://pauling.mbu.iisc.ernet.in/~supfam   Grouping of sequence families into superfamilies
  SYSTERS   http://systers.molgen.mpg.de/   Classification of protein sequences into disjoint clusters with annotations from various other resources
  TMPDB   http://bioinfo.si.hirosaki-u.ac.jp/~TMPDB   Experimentally-characterized transmembrane topologies
Proteome Resources
  AAindex   http://www.genome.ad.jp/dbget/   Physicochemical properties of peptides
  GELBANK   http://gelbank.anl.gov   2D-gel electrophoresis patterns from completed genomes
  PEP: Predictions for Entire Proteomes   http://cubic.bioc.columbia.edu/pep/   Signalling domain sequences
  Proteome Analysis Database   http://www.ebi.ac.uk/proteome/   Online application of interpro and clustr for the functional classification of proteins in whole genomes
  REBASE   http://rebase.neb.com/rebase/rebase.html   Restriction enzymes and associated methylases
  SWISS-2DPAGE   http://www.expasy.ch/ch2d/   Annotated two-dimensional polyacrylamide gel electrophoresis database
RNA Sequences
  5S Ribosomal RNA Database   http://biobases.ibch.poznan.pl/5SData   5S rRNA sequences
  16S and 23S Ribosomal RNA Mutation Database   http://www.fandm.edu/Departments/
Biology/Databases/RNA.html
  16S and 23S rRNA mutations
  ACTIVITY   http://wwwmgs.bionet.nsc.ru/
mgs/systems/activity/
  Functional DNA/RNA site activity
  ARED   http://rc.kfshrc.edu.sa/ared/   AU-rich element-containing mRNAs
  Database for mobile group II introns   http://www.fp.ucalgary.ca/group2introns   Database for mobile group II introns
  Collection of mRNA-like Noncoding RNAs   http://biobases.ibch.poznan.pl/ncRNA/   Non-protein-coding RNA transcripts
  European Ribosomal RNA Database   http://oberon.rug.ac.be:8080/
rRNA/index.html
  Alignment of ribosomal RNA sequences with secondary structure information
  Guide RNA Database   http://biosun.bio.tu-darmstadt.de/
goringer/gRNA/gRNA.html
  Guide RNA sequences
  HyPaLib   http://bibiserv.techfak.
uni-bielefeld.de/HyPa/
  Structural elements characteristic for classes of RNA
  Intronerator   http://www.cse.ucsc.edu/
~kent/intronerator/
  RNA splicing and gene structure in C. elegans; alignments of C. briggsae and C. elegans genomic sequences
  IRESdb   http://ifr31w3.toulouse.inserm.fr/
IRESdatabase/
  Internal ribosome entry sites
  NCIR   http://prion.bchs.uh.edu/bp_type/   Non-standard base-base interactions in known RNA structures
  Noncoding regulatory RNAs Database   http://biobases.ibch.poznan.pl/ncRNA   Noncoding RNAs with regulatory functions
  Noncoding regulatory RNAs database   http://www.prl.msu.edu/PLANTncRNAs/   Plant non-protein coding RNAs with relevant gene expression information
  Plant snoRNA DB   http://bioinf.scri.sari.ac.uk/
cgi-bin/plant_snorna/home
  snoRNA genes in plant species
  PLMItRNA   http://bighost.area.ba.cnr.it/PLMItRNA/   Mitochondrial tRNA genes and molecules in photosynthetic eukaryotes
  Pseudobase   http://wwwbio.leidenuniv.nl/
~Batenburg/PKB.html
  Information on RNA pseudoknots
  Rfam   http://www.sanger.ac.uk/Software/Rfam/   Non-coding RNA families
  Ribosomal Database Project (RDP II)   http://rdb.cme.msu.edu   rRNA sequence data, analysis tools, alignments and phylogenies
  RISCC   http://ulises.umh.es/RISSC   Ribosomal 16S-23S RNA gene spacer regions
  RNA Modification Database   http://medlib.med.utah.edu/RNAmods/   Naturally modified nucleosides in RNA
  SELEXdb   http://wwwmgs.bionet.nsc.ru/
mgs/systems/selex/
  Selected DNA/RNA functional site sequences
  Small RNA Database   http://mbcr.bcm.tmc.edu/smallRNA   Direct sequencing of small RNA sequences from prokaryotes and eukaryotes
  SRPDB   http://psyche.uthct.edu/dbs/
SRPDB/SRPDB.html
  Signal recognition particle RNA, SRP protein and SRP receptor sequences and alignments
  Subviral RNA database   http://132.210.163.235/subviral/home.cgi   Database of viroids and viroid-like RNAs
  tmRDB   http://psyche.uthct.edu/dbs/
tmRDB/tmRDB.html
  tmRNA (10Sa RNA) sequences and alignments
  The tmRNA Website   http://www.indiana.edu/~tmrna   tmRNA sequences, foldings, and alignments
  tRNA Sequences   http://www.uni-bayreuth.de/
departments/biochemie/trna/
  tRNA and tRNA gene sequences
  UTRdb/UTRsite   http://bighost.area.ba.cnr.it/srs6/   5' and 3' UTRs of eukaryotic mRNAs and relevant functional patterns
  Yeast snoRNA Database   http://www.bio.umass.edu/biochem/
rna-sequence/Yeast_snoRNA_Database/
snoRNA_DataBase.html
  Yeast small nucleolar RNAs
Retrieval Systems and Database Structure
  TESS   http://www.cbil.upenn.edu/tess   Transcription element search system
  Virgil   http://www.infobiogen.fr/services/virgil   Database interconnectivity
Structure
  ASTRAL   http://astral.stanford.edu/   Sequences of domains of known structure, selected subsets, and sequence-structure correspondences
  BioImage   http://www.bioimage.org   Searchable database of multidimensional biological images
  BioMagResBank   http://www.bmrb.wisc.edu/   NMR spectroscopic data from proteins, peptides, and nucleic acids
  CADB   http://144.16.71.148   Conformation angles of protein structures, with associated crystallographic data
  CATH   http://www.biochem.ucl.ac.uk/bsm/cath/   Hierarchical classification of protein domain structures
  CE   http://cl.sdsc.edu/ce.html   Combinatorial Extension: A Resource to Compute and Review 3-D Protein Structure Alignments
  CKAAPs DB   http://ckaap.sdsc.edu   Structurally-similar proteins with dissimilar sequences
  CSD   http://www.ccdc.cam.ac.uk/
prods/csd/csd.html
  Crystal structure information for organic and metal organic compounds
  Database of Macromolecular Movements   http://bioinfo.mbb.yale.edu/MolMovDB/   Descriptions of protein and macromolecular motions, including movies
  Decoys 'R' Us   http://dd.stanford.edu/   Computer-generated protein conformations based on sequence data
  DSDBASE   http://www.ncbs.res.in/%7Efaculty/
mini/dsdbase/dsdbase.html
  Native and modeled disulfide bonds in proteins
  DSMM   http://projects.eml.org/mcm/database/dsmm   Database of simulated molecular motions
  E-MSD   http://www.ebi.ac.uk/msd   Collected data on macromolecular structures
  FAMSBASE   http://famsbase.bio.nagoya-u.ac.jp/
famsbase
  Protein three-dimensional structural models
  Gene3D   http://www.biochem.ucl.ac.uk/bsm
cath_new/Gene3D/
  Precalculated structural assignments for genes within whole genomes
  GTOP   http://spock.genes.nig.ac.jp/
~genome/gtop.html
  Structures of small molecules (hetero-compounds)
  HIC-Up   http://xray.bmc.uu.se/hicup/   Structures of small molecules (hetero-compounds)
  HSSP   http://www.sander.ebi.ac.uk/hssp/   Structural families and alignments; structurally-conserved regions and domain architecture
  IMB Jena Image Library of Biological Macromolecules   http://www.imb-jena.de/IMAGE.html   Visualization and analysis of three-dimensional biopolymer structures
  ISSD   http://www.protein.bio.msu.su/issd/   Integrated sequence and structural information
  LPFC   http://www-smi.stanford.edu/
projects/helix/LPFC/
  Library of protein family core structures
  MMDB   http://www.ncbi.nlm.nih.gov/Structure/   All experimentally-determined three-dimensional structures, linked to NCBI Entrez
  ModBase   http://guitar.rockefeller.edu/modbase   Annotated comparative protein structure models
  MolMovDB   http://MolMovDB.org   Database of macromolecular movements
  NDB   http://ndbserver.rutgers.edu/   Nucleic acid-containing structures
  NTDB   http://ntdb.chem.cuhk.edu.hk   Thermodynamic data for nucleic acids
  PALI   http://pauling.mbu.iisc.ernet.in/~pali   Phylogeny and alignment of homologous protein structures
  PASS2   http://ncbs.res.in/%7Efaculty/
mini/campass/pass.html
  Structural motifs of protein superfamilies
  PDB   http://www.rcsb.org/pdb/   Structure data determined by X-ray crystallography and NMR
  PDB-REPRDB   http://www.cbrc.jp/papia/papia.html   Representative protein chains, based on PDB entries
  PDBsum   http://www.biochem.ucl.ac.uk/bsm/pdbsum   Summaries and analyses of PDB structures
  PRESAGE   http://presage.berkeley.edu/   Protein structures with experimental and predictive annotations
  ProTherm   http://www.rtc.riken.go.jp/
jouhou/protherm/protherm.html
  Thermodynamic data for wild-type and mutant proteins
  PSSH   http://srs3d.ebi.ac.uk/   Alignment between protein sequences and tertiary structures
  RESID   http://www-nbrf.georgetown.edu/
pirwww/dbinfo/resid.html
  Protein structure modifications
  RNABase   http://www.rnabase.org   RNA-containing structures from PDB and NDB
  SCOP   http://scop.mrc-lmb.cam.ac.uk/scop/   Familial and structural protein relationships
  SCOR   http://scor.lbl.gov   RNA structural relationships
  SLoop   http://www-cryst.bioc.cam.ac.uk/~sloop/   Classification of protein loops
  Structure-Superposition Database   http://ssd.rbvi.ucsf.edu   Pairwise superposition of TIM-barrel structures
  SUPERFAMILY   http://supfam.org   Assignments of proteins to structural superfamilies
  TOPS   http://www.tops.leeds.ac.uk/   Topology of protein structure
Transgenics
  Cre Transgenic Database   http://www.mshri.on.ca/nagy/   Cre transgenic mouse lines
  Transgenic/Targeted Mutation Database   http://tbase.jax.org/   Information on transgenic animals and targeted mutations
Micellaneous Biomedical Content
  BAliBASE   http://www-igbmc.u-strasbg.fr/
BioInfo/BAliBASE2/index.html
  Benchmark database for comparison of multiple sequence alignments
  Cytokine Gene Polymorphism in Human Disease   http://bris.ac.uk/pathandmicro/
services/GAI/cytokine4.htm
  Cytokine gene polymorphism literature database
  DBcat   http://www.infobiogen.fr/services/dbcat/   Catalog of databases
  GlycoSuiteDB   http://www.glycosuite.com   N- and O-linked glycan structures and biological source information
  HOX-PRO   http://www.iephb.nw.ru/labs/lab38/
spirov/hox_pro/hox-pro00.html
  Clustering of homeobox genes
  Imprinted Genes and Parent-of-Origin Effects   http://www.otago.ac.nz/IGC   Imprinted genes and parent-of-origin effects in animals
  LocusLink/RefSeq   http://www.ncbi.nlm.nih.gov/LocusLink/   Curated sequence and descriptive information about genetic loci
  MPDB   http://www.biotech.ist.unige.it/
interlab/mpdb.html
  Information on synthetic oligonucleotides proven useful as primers or probes
  NCBI Taxonomy Browser   http://www.ncbi.nlm.nih.gov/
Taxonomy/taxonomyhome.html
  Names of all organisms that are represented in the genetic databases with at least one nucleotide or protein sequence
  PDBsum   http://srs.ebi.ac.uk/   Molecular Probe Database
  probeBase   http://www.microbial-ecology.net/
probebase/
  rRNA-targeted oligonucleotide probe sequences, DNA microarray layouts and associated information
  PubMed   http://www.ncbi.nlm.nih.gov/PubMed/   MEDLINE and Pre-MEDLINE citations
  RefSeq   http://www.ncbi.nih.gov/RefSeq/   Reference sequence standards for genomes, genes, transcripts and proteins
  RIDOM   http://www.ridom.de/   rRNA (16S and ITS) sequence-based identification of medical microorganisms
  SWEET-DB   http://www.dkfz-heidelberg.de/
spec2/sweetdb
  Annotated carbohydrate structure and substance information
  The Pharmacogenomics and Pharmacogenetics Knowledge Base   http://www.pharmgkb.org   Variation in drug response based on human variation
  Tree of Life   http://tolweb.org/tree/phylogeny.html   Information on phylogeny and biodiversity
  Vectordb   http://life.nthu.edu.tw/
~g854202/Vecdtb.html
  Characterization and classification of nucleic acid vectors
  VirOligo   http://viroligo.okstate.edu   Virus-specific oligonucleotides for PCR and hybridization

Original compilation by A. D. Baxevanis (Nucl. Acids Res. 29 [2001] 1-10) - updated June 2003
 
punkt
  Impress  /  23-6-2003  /  R. Bergmann  /  http://www.biologie.uni-hamburg.de/molinkp.htm search