ENTRY       EC 5.3.1.1
NAME        Triose-phosphate isomerase
            Phosphotriose isomerase
            Triosephosphate mutase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Glyceraldehyde-3-phosphate ketol-isomerase
REACTION    D-Glyceraldehyde 3-phosphate = Glycerone phosphate
SUBSTRATE   D-Glyceraldehyde 3-phosphate
PRODUCT     Glycerone phosphate
INHIBITOR   2-Phosphoglycolate
            Phosphoglycolohydroxamate
COMMENT     2-Phosphoglycolate and phosphoglycolohydroxamate are transition
            state analogue/inhibitor. Crystal structures of the inhibitor
            complexes (Biochemistry, 1990, 29, 6619-6625; 1991, 30, 5821-5826;
            1994, 33, 2830-2837).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00710  Carbon fixation
DISEASE     MIM: 190450  Triosephosphate isomerase-1; Hemolytic anemia due to
                         triosephosphate isomerase deficiency (3)
MOTIF       PS: PS00171  [AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-G
GENES       MJA: MJ1528(tpiA)
            MTH: MTH1041
            ECO: b3919(tpiA)
            HIN: HI0678(tpiA)
            HPY: HP0194
            BSU: tpi(tim)
            MGE: MG431(tpiA)
            MPN: C12_orf244(tpiA)
            SYN: slr0783(tpi)
            SCE: YDR050C(TPI1)
            HSA: TPI1
STRUCTURES  PDB: 1AG1  1BTM  1HTI  1ML1  1MSS  1MTM  1TIM  1TMH  1TPB  1TPC  
                 1TPD  1TPE  1TPF  1TPH  1TPU  1TPV  1TPW  1TRD  1TRE  1TRI  
                 1TSI  1TTI  1TTJ  1YPI  2YPI  3TIM  3YPI  4TIM  5TIM  6TIM  
                 7TIM  
DBLINKS     University of Geneva ENZYME DATA BANK: 5.3.1.1
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.1
            SCOP (Structural Classificaion of Proteins): 5.3.1.1
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