ENTRY       EC 4.1.3.3
NAME        N-Acetylneuraminate lyase
            N-Acetylneuraminic acid aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     N-Acetylneuraminate pyruvate-lyase
REACTION    N-Acetylneuraminate = N-Acetyl-D-mannosamine + Pyruvate
SUBSTRATE   N-Acetylneuraminate
            N-Glycoloyl-neuraminate
            O-Acetylated sialic acid
PRODUCT     N-Acetyl-D-mannosamine
            Pyruvate
COMMENT     Also acts on N-glycoloyl-neuraminate and on O-acetylated sialic
            acids, other than O4-acetylated derivatives.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
MOTIF       PS: PS00665  [GSA]-[LIVM]-[LIVMFY]-x(2)-G-[ST]-[TG]-G-E-[GASNF]-
                         x(6)-[EQ]
            PS: PS00666  Y-[DNS]-[LIVMF]-P-x(2)-[ST]-x(3)-[LIVM]-x(13,14)-
                         [LIVM]-x-[AG]-[LIVM]-K-[DEQF]-[STAC]
GENES       ECO: b3225(nanA)
            HIN: HI0142(nanA)
STRUCTURES  PDB: 1NAL  
DBLINKS     University of Geneva ENZYME DATA BANK: 4.1.3.3
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.3
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