ENTRY       EC 3.8.1.4
NAME        Thyroxine deiodinase
            Thyroxine 5-deiodinase
            Diiodothyronine 5'-deiodinase
            Iodothyronine outer ring monodeiodinase
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
SYSNAME     L-Thyroxine iodohydrolase (reducing)
REACTION    L-Thyroxine + AH2 = 3,5,3'-L-Triiodo-L-thyronine + Iodide +
            A + H+
SUBSTRATE   L-Thyroxine
            AH2
PRODUCT     3,5,3'-L-Triiodo-L-thyronine
            Iodide
            A
            H+
COMMENT     A group of enzymes, removing iodine atoms sequentially
            from thyroxine. Distinct enzymes may exist acting on the
            inner and outer rings of iodinated thyronine.
MOTIF       PS: PS00014  [KRHQSA]-[DENQ]-E-L>
            PS: PS00194  [LIVMF]-[LIVMSTA]-x-[LIVMFYC]-[FYWSTHE]-x(2)-[FYWGTN]-
                         C-[GATPLVE]-[PHYSTA]-C-x(6)-[LIVMFYWT]
GENES       HSA: DIO1(TXDI1)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.8.1.4
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.4
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