ENTRY       EC 2.4.99.8
NAME        alpha-N-Acetyl-neuraminate alpha-2,8-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-
            $galactoside alpha-2,8-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate + alpha-N-Acetylneuraminyl-
            $2,3-beta-D-galactosyl-R = CMP + alpha-N-Acetylneuraminyl-
            $2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R
SUBSTRATE   CMP-N-acetylneuraminate
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-R
            Ganglioside
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-
            $D-galactosyl-R
COMMENT     Gangliosides act as acceptors.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DISEASE     MIM: 601123  Sialyltransferase 8 (alpha-N-acetylneuraminate:
GENES       HSA: SIAT8(Hs.82527)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.99.8
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.8
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