ENTRY       EC 2.4.99.2
NAME        Monosialoganglioside sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-
            $(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
            $ N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate +
            D-Galctosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-
            $galactosyl-D-glucosylceramide = CMP +
            N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-
            $acetylneuraminyl)-D-galactosyl-D-glucosylceramide
SUBSTRATE   CMP-N-acetylneuraminate
            D-Galctosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-
            $galactosyl-D-glucosylceramide
PRODUCT     CMP
            N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-
            $acetylneuraminyl)-D-galactosyl-D-glucosylceramide
COMMENT     May be identical with EC 2.4.99.4.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       HSA: SIAT2
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.99.2
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.2
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