ENTRY       EC 2.4.99.1
NAME        beta-Galactoside alpha-2,6-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-
            -glucosamine alpha-2,6-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate +
            beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP +
            alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosamine
SUBSTRATE   CMP-N-acetylneuraminate
            beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosamine
COMMENT     The terminal beta-D-galactosyl residue of the oligosaccharide
            of glycoproteins, as well as lactose, can act as acceptor.
DISEASE     MIM: 109675  Sialyltransferase 1 (beta-galactoside
                         alpha-2,6-sialytransferase)
GENES       HSA: SIAT1(Hs.2554)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.99.1
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.1
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