ENTRY       EC 2.4.2.29
NAME        Queuine tRNA-ribosyltransferase
            tRNA-guanine transglycosylase
            Guanine insertion enzyme
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     tRNA-guanine:queuine tRNA-ribosyltransferase
REACTION    tRNA guanine + Queuine = tRNA queuine + Guanine
SUBSTRATE   tRNA guanine
            Queuine
PRODUCT     tRNA queuine
            Guanine
COMMENT     The enzyme also catalyses the exchange of precursors of
            queuine and of guanine itself for guanine located in the
            first position of certain tRNA anticodons.
MOTIF       PS: PS00972  G-[LIVMFY]-x(1,3)-[AGC]-[NA]-x-C-[FY]-[LIVMC]-[NS]-
                         [SACV]-x-[LIVM]-Q
            PS: PS00973  Y-x-L-x-[SAG]-[LIVMFT]-x(2)-H-x-G-x(4,5)-G-H-Y
GENES       MJA: MJ0436
            MTH: MTH176
            ECO: b0406(tgt)
            HIN: HI0244(tgt)
            HPY: HP0281
            BSU: tgt
            SYN: slr0713(tgt)
STRUCTURES  PDB: 1WKE  1WKF  1WKD  1PUD  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.2.29
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.29
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