ENTRY       EC 2.4.1.17
NAME        Glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
REACTION    UDPglucuronate + Acceptor = UDP + Acceptor beta-D-glucuronoside
SUBSTRATE   UDPglucuronate
            Acceptor
PRODUCT     UDP
            Acceptor beta-D-glucuronoside
COMMENT     This entry denotes a family of enzymes accepting a wide range
            of substrates, including phenols, alchols, amines and fatty acids.
            Some of the activities catalysed were priviously listed separately
            as EC 2.4.1.42, 59, 61, 76, 77, 84, 107 and 108. A temporary
            nomenclature for the various forms, whose delineation is in a
            state of flux, is suggested in 513.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00150  Androgen and estrogen metabolism
            PATH: MAP00500  Starch and sucrose metabolism
DISEASE     MIM: 600067  UDP-glucuronyltransferase (steroid metabolizing), 4
            MIM: 600219  UDP-glucuronyltransferase-2B (steroid metabolizing),
                         15
MOTIF       PS: PS00375  W-x(2)-Q-x(2)-[LIVM]-L-x-H-x(4)-A-F-[LIVM]-[STAG]-x-
                         [STAG]-G-x(2)-[STAG]-x(3)-[STAG]-[LIVM]-x(3)-[LIVM]-P-
                         [LIVM]-x(3)-P-[LIVMF](2)-x-[DE]-Q
GENES       HSA: UGT1(UGT1A1) UGT2B(UGT2)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.1.17
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.17
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