ENTRY       EC 2.4.1.11
NAME        Glycogen(starch) synthase
            UDPglucose--glycogen glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:glycogen 4-alpha-D-glucosyltransferase
REACTION    UDPglucose + (1,4-alpha-D-Glucosyl)n = UDP +
            (1,4-alpha-D-Glucosyl)n+1
SUBSTRATE   UDPglucose
            (1,4-alpha-D-Glucosyl)n
            Glucosylated glycogenin
PRODUCT     UDP
            (1,4-alpha-D-Glucosyl)n+1
COMMENT     The recommended name will vary according to the source of the
            enzyme and the nature of its synthetic product (cf. phosphorylase
            EC 2.4.1.1). Glycogen synthase from animal tissues is a complex of
            a catalytic sub-unit and the protein glycogenin. The enzyme
            requires glucosylated glycogenin as a primer; this is the reaction
            product of EC 2.4.1.186. A similar enzyme utilizes ADP-glucose
            (EC 2.4.1.29).
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DISEASE     MIM: 138570  Glycogen synthase; {Non-insulin dependent diabetes
                         mellitus, susceptibility to} (2)
            MIM: 138571  Glycogen synthase-2 (liver); Glycogen synthase, liver,
                         deficiency of, 240600 (1)
GENES       MJA: MJ1606
            SYN: GSY2) sll1202(YLR258W sll1393(glgA)
            SCE: YFR015C(GSY1) YLR258W(GSY2)
            HSA: GYS1(GYS) GYS2
DBLINKS     University of Geneva ENZYME DATA BANK: 2.4.1.11
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.11
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