ENTRY       EC 1.3.99.1
NAME        Succinate dehydrogenase
            Succinic dehydrogenase
            Fumarate reductase
            Fumaric hydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     Succinate:(acceptor) oxidoreductase
REACTION    Succinate + Acceptor = Fumarate + Reduced acceptor
SUBSTRATE   Succinate
            Acceptor
PRODUCT     Fumarate
            Reduced acceptor
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     A flavoprotein (FAD) containing iron-sulfur centres. A component
            of EC 1.3.5.1. (EC 1.3.5.1 Succinate dehydrogenase)
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00190  Oxidative phosphorylation
            PATH: MAP00650  Butanoate metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
DISEASE     MIM: 185470  Succinate dehydrogenase 1, iron sulphur (Ip) subunit;
                         ?Myopathy due to succinate dehydrogenase deficiency (1)
            MIM: 600857  Succinate dehydrogenase 2, flavoprotein (Fp) subunit;
                         Leigh syndrome (3)
MOTIF       PS: PS00190  C-{CPWHF}-{CPWR}-C-H-{CFYW}
            PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{cpdhtmEKRHFYW}-C
            PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00504  R-[ST]-H-[ST]-x(2)-A-x-G-G
GENES       MJA: MJ0033 MJ0092
            MTH: MTH139 MTH1502 MTH1850
            ECO: b0721(sdhC) b0722(sdhD) b0723(sdhA) b0724(sdhB) b4151(frdD)
                 b4152(frdC) b4153(frdB) b4154(frdA)
            HIN: HI0834(frdB) HI0835(frdA)
            HPY: HP0191(frdB) HP0192(frdA)
            BSU: sdhA(citF) sdhB sdhC
            SYN: sdhD) sll0823(sdhB) sll1625(sdhB) slr1233(frdA)
                 ssr3409(ECOLI_696
            HSA: SDHB(SDH1)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.3.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.1
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