ENTRY       EC 1.3.1.2
NAME        Dihydropyrimidine dehydrogenase (NADP+)
            Dihydrothymine dehydrogenase
            Dihydrouracil dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5,6-Dihydrouracil:NADP+ oxidoreductase
REACTION    5,6-Dihydrouracil + NADP+ = Uracil + NADPH
SUBSTRATE   5,6-Dihydrouracil
            NADP+
            Dihydrothymine
PRODUCT     Uracil
            NADPH
            Thymine
COMMENT     Also acts on dihydrothymine.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
DISEASE     MIM: 274270  Dihydropyrimidine dehydrogenase; Thymine-uraciluria
                         (1); {Fluorouracil toxicity, sensitivity to} (1)
GENES       HSA: DPYD
DBLINKS     University of Geneva ENZYME DATA BANK: 1.3.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.2
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