ENTRY       EC 1.2.1.2
NAME        Formate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Formate:NAD+ oxidoreductasee
REACTION    Formate + NAD+ = CO2 + NADH
SUBSTRATE   Formate
            NAD+
PRODUCT     CO2
            NADH
COMMENT     Together with EC 1.12.1.2, forms a system previously known as
            formate hydrogenlyase.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00065  [LIVM]-[AG]-[LIVMT]-[LIVMFY]-[AG]-x-G-[NHKRQSC]-[LIVM]-
                         G-x(13,14)-[LIVMT]-x(2)-[FYCTH]-[DNSTK]
            PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00490  [STA]-x-[STAC](2)-x(2)-[STA]-D-[LIVMY](2)-L-P-x-
                         [STAC](2)-x(2)-E
            PS: PS00551  [STAN]-x-[CH]-x(2,3)-C-[STAG]-[GSTVF]-x-C-x-[LIVMFYW]-
                         x-[LIVMA]-x(3,4)-[DNQKH]
            PS: PS00670  [DEST]-[LIVMFY](2)-x(2)-[SAC]-[DQ]-[LIVMF](2)-x-
                         [LIVMFY]-[HN]-x-[PV]
            PS: PS00671  [LIVMFYA]-[KHP]-x-[GSD]-x-[LIVMFYW](3)-N-x-[STAGC]-R-
                         [GP]-x-[LIVM]-[LIVMC]-[DNV]
            PS: PS00932  A-x(3)-[GDT]-I-x-[DNQTK]-x-[DEA]-x-[LIVM]-x-[LIVMC]-x-
                         [NS]-x(2)-[GS]-x(5)-A-x-[LIVM]-[ST]
GENES       MJA: MJ0005 MJ0006 MJ0155 MJ0264 MJ0265 MJ0295 MJ0515 MJ0516
                 MJ1027 MJ1353 MJ1363
            MTH: MTH1139 MTH1140 MTH1238 MTH1239 MTH1547 MTH1552 MTH1714
                 MTH1736 MTH1737 MTH397 MTH398
            ECO: b1474(fdnG) b1475(fdnH) b1476(fdnI) b3892(fdoI) b3893(fdoH)
                 b3894(fdoG) b4079(fdhF)
STRUCTURES  PDB: 2NAD  2NAC  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.2.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.2
            SCOP (Structural Classificaion of Proteins): 1.2.1.2
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