ENTRY       EC 1.2.1.1
NAME        Formaldehyde dehydrogenase (glutathione)
            Formic dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Formaldehyde:NAD+ oxidoreductase (glutathione-formylating)
REACTION    Formaldehyde + Glutathione + NAD+ = S-Formylglutathione + NADH
SUBSTRATE   Formaldehyde
            Glutathione
            NAD+
            2-Oxoaldehyde
PRODUCT     S-Formylglutathione
            NADH
COMMENT     Some 2-oxoaldehydes are also oxidized. In the reverse direction,
            NADPH can replace NADH.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00680  Methane metabolism
DISEASE     MIM: 103710  Alcohol dehydrogenase (class III), chi polypeptide
            MIM: 136490  Formaldehyde dehydrogenase
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVAC]
GENES       ECO: b0356(adhC)
            HIN: HI0185(adhC)
            BSU: adhB
            SYN: sll0990
            SCE: YDL168W(SFA1)
            HSA: FDH
STRUCTURES  PDB: 1TEH  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.1
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