ENTRY       EC 1.12.1.2
NAME        Hydrogen dehydrogenase
            Hydrogenase
CLASS       Oxidoreductases
            Acting on hydrogen as donor
            With NAD+ or NADP+ as acceptor
SYSNAME     hydrogen:NAD+ oxidoreductase
REACTION    H2 + NAD+ = H+ + NADH
SUBSTRATE   H2
            NAD+
PRODUCT     H+
            NADH
COFACTOR    Iron
            Nickel
            Flavin
COMMENT     Contains iron, nickel and flavin.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00507  R-G-[LIVMF]-E-x(15)-[QE]-R-x-C-G-[LIVM]-C
            PS: PS00508  [FY]-D-P-C-[LIM]-[ASG]-C-x(2)-H
            PS: PS00641  P-x(2)-C-[YW]-x(7)-G-x-C-R-x-C
            PS: PS00642  C-P-x-C-[DE]-x-[GS](2)-x-C-x-L-Q
            PS: PS00643  R-C-[LIVM]-x-C-x-R-C-[LIVM]-x-F
            PS: PS00644  G-A-G-[AR]-Y-[LIVM]-C-G-[DE](2)-[STA](2)-[LI](2)-[EN]-S
            PS: PS00645  E-S-C-G-x-C-x-P-C-R-x-G
GENES       SYN: sll1223(hoxU)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.12.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.12.1.2
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