ENTRY       EC 1.1.1.88
NAME        Hydroxymethylglutaryl-CoA reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Mevalonate:NAD+ oxidoreductase (CoA-acetylating)
REACTION    (S)-Mevalonate + CoA + 2 NAD+ = (S)-3-Hydroxy-3-methylglutaryl-CoA
            + 2 NADH
SUBSTRATE   (S)-Mevalonate
            CoA
            NAD+
PRODUCT     (S)-3-Hydroxy-3-methylglutaryl-CoA
            NADH
MOTIF       PS: PS00066  [RKH]-x(6)-D-x-M-G-x-N-x-[LIVM]
            PS: PS00318  [LIVM]-G-x-[LIVM]-G-G-[AG]-T
GENES       HSA: HMGCR
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.88
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.88
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