ENTRY       EC 1.1.1.49
NAME        Glucose-6-phosphate 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glucose-6-phosphonate:NADP+ 1-oxoreductase
REACTION    D-Glucose 6-phosphate + NADP+ = D-Glucono-1,5-lactone 6-phosphate
            + NADPH
SUBSTRATE   D-Glucose 6-phosphate
            beta-D-Glucose
            Sugar
            NADP+
            NAD+
PRODUCT     D-Glucono-1,5-lactone 6-phosphate
            NADPH
            NADH
INHIBITOR   Fatty acid
COMMENT     Also acts slowly on beta-D-glucose and other sugars. Certain
            preparations also reduce NAD+ as well as NADP+.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00480  Glutathione metabolism
DISEASE     MIM: 305900  Glucose-6-phosphate dehydrogenase; G6PD deficiency
                         (3); Favism (3); Hemolytic anemia due to G6PD
                         deficiency (3)
MOTIF       PS: PS00069  D-H-Y-L-G-K-E
GENES       ECO: b1852(zwf)
            HIN: HI0558(zwf)
            HPY: HP1101 HP1102(devB)
            BSU: yqjJ(zwf)
            SYN: sll1479(devB) slr1843(zwf)
            SCE: YNL241C(ZWF1)
            HSA: G6PD(G6PD1)
STRUCTURES  PDB: 1DPG  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.49
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.49
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