ENTRY       EC 1.1.1.23
NAME        Histidinol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Histidinol:NAD+ oxidoreductase
REACTION    L-Histidinol + 2 NAD+ = L-Histidine + 2 NADH
SUBSTRATE   L-Histidinol
            L-Histidinal
            NAD+
PRODUCT     L-Histidine
            NADH
COMMENT     Also oxidizes L-histidinal. The Neurospora enzyme also catalyses
            the reaction of EC 3.5.4.19 and 3.6.1.31.
            (EC 3.5.4.19 Phosphoribosyl-AMP cyclohydrolase)
            (EC 3.6.1.31 Phosphoribosyl-ATP pyrophosphatase)
PATHWAY     PATH: MAP00340  Histidine metabolism
MOTIF       PS: PS00611  I-D-x(2)-A-G-P-[ST]-E-[LIVMA](5)-x(3)-A-x(4)-[LIVM]-
                         [AV]-[SA]-D-[LIVM](2)-[SA]-x-A-E-H
GENES       MJA: MJ1456
            MTH: MTH225
            ECO: b2020(hisD)
            HIN: HI0469(hisD)
            BSU: hisD
            SYN: slr0682(hisD) slr1848(hisD)
            SCE: YCL030C(HIS4)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.23
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.23
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