ENTRY       EC 1.1.1.219
NAME        Dihydrokaempferol 4-reductase
            Dihydroflavanol 4-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-3,4-Leucopelargonidin:NADP+ 4-oxidoreductase
REACTION    cis-3,4-Leucopelargonidin + NADP+ = (+)-Dihydrokaempferol + NADPH
SUBSTRATE   cis-3,4-Leucopelargonidin
            NADP+
            NAD+
            (+)-Dihydroquercetin
            (+)-Dihydromyricetin
PRODUCT     (+)-Dihydrokaempferol
            NADPH
            NADH
COMMENT     Also acts, in the reverse direction, on (+)-dihydroquercetin and
            (+)-dihydromyricetin; each dihydroflavonol is reduced to the
            corresponding cis-flavan-3,4-diol.  NAD+ can act instead of NADP+,
            more slowly.  Involved in the biosynthesis of anthocyanidins in
            plants.
PATHWAY     PATH: MAP00940  Biosynthesis of flavonoids
GENES       SYN: slr1706(dfrA)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.219
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.219
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