ENTRY       EC 1.1.1.218
NAME        Morphine 6-dehydrogenase
            Naloxone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Morphine:NAD(P)+ 6-oxidoreductase
REACTION    Morphine + NAD+ or NADP+ = Morphinone + NADH or NADPH
SUBSTRATE   Morphine
            NAD+
            NADP+
PRODUCT     Morphinone
            NADH
            NADPH
EFFECTOR    2-Mercaptoethanol
COMMENT     Also acts on some other alkaloids, including codeine, normorphine
            and ethylmorphine, but only very slowly on 7,8-saturated
            derivatives such as dihydromorphine and dihydrocodeine.  In the
            reverse direction, also reduces naloxone to the 6alpha-hydroxy
            analogue.  Activated by 2-mercaptoethanol.
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.218
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.218
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