ENTRY       EC 1.1.1.21
NAME        Aldehyde reductase
            Aldose reductase
            Polyol dehydrogenase(NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Alditol:NAD(P)+ 1-oxidoreductase
REACTION    Alditol + NAD+ or NADP+ = Aldose + NADH or NADPH
SUBSTRATE   Alditol
            NAD+
            NADP+
PRODUCT     Aldose
            NADH
            NADPH
INHIBITOR   Tolrestat
            HOE-252
            Zopolrestat
            Salfredin
COMMENT     Wide specificity.
            Inhibited by zopolrestat. This structure was determined to 1.8 A
            resolution (Proc.Natl.Acad.Sci.USA 90 9847-51(1993)).
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00620  Pyruvate metabolism
DISEASE     MIM: 103880  Aldehyde reductase-1 (low Km aldose reductase)
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
GENES       HSA: ALDR1
STRUCTURES  PDB: 2ACU  2ACS  2ACR  2ACQ  1ABN  1ADS  1DLA  1MAR  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.21
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.21
            SCOP (Structural Classificaion of Proteins): 1.1.1.21
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