ENTRY       EC 1.1.1.189
NAME        Prostaglandin-E2 9-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate:
            $NADP+ 9-oxidoreductase
REACTION    (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate +
            NADP+ =
            (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate +
            NADPH
SUBSTRATE   (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate
            NADP+
            Prostaglandin E2
PRODUCT     (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
            NADPH
            Prostaglandin F2alpha
COMMENT     Reduces prostaglandin E2 to prostaglandin F2alpha.  A number of
            other 9-oxo- and 15-oxo-prostaglandin derivatives can also be
            reduced to the corresponding hydroxy compounds.  May be identical
            with EC 1.1.1.197.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
MOTIF       PS: PS00061  [LIVSPADK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFR]-[LIVMTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFWGAPTH]-[GSACQRHM]
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.189
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.189
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