ENTRY       EC 1.1.1.159
NAME        7alpha-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     7alpha-Hydroxysteroid:NAD+ 7-oxidoreductase
REACTION    3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NAD+ =
            3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + NADH
SUBSTRATE   3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate
            NAD+
            NADP+
PRODUCT     3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate
            NADH
            NADPH
COMMENT     Catalyses the oxidation of the 7alpha-hydroxyl group of bile
            acids and alcohols both in their free and conjugated forms.
            The Bacteroides fragillis and Clostridium enzymes can also
            utilize NADP+.
            The mammalian enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
MOTIF       PS: PS00061  [LIVSPADK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFR]-[LIVMTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFWGAPTH]-[GSACQRHM]
GENES       ECO: b1619(hdhA)
STRUCTURES  PDB: 1AHH  1AHI  1FMC  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.159
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.159
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