ENTRY       EC 1.1.1.149
NAME        20alpha-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     20alpha-Hydroxysteroid:NAD(P)+ 20-oxidoreductase
REACTION    17alpha,20alpha-Dihydroxypregn-4-en-3-one + NAD+ or NADP+ =
            17alpha-Hydroxyprogesterone + NADH or NADPH
SUBSTRATE   17alpha,20alpha-Dihydroxypregn-4-en-3-one
            NADP+
            NAD+
PRODUCT     17alpha-Hydroxyprogesterone
            NADPH
            NADH
COMMENT     A-specific with respect to NAD(P)+ (cf. EC 1.1.1.62).
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.149
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.149
///