ENTRY       EC 1.1.1.14
NAME        L-Iditol 2-dehydrogenase
            Polyol dehydrogenase
            Sorbitol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Iditol:NAD+ 2-oxidoreductase
REACTION    L-Iditol + NAD+ = L-Sorbose + NADH
SUBSTRATE   L-Iditol
            NAD+
            D-Glucitol
PRODUCT     L-Sorbose
            NADH
            D-Fructose
COMMENT     Also acts on D-glucitol (giving D-fructose) and other
            closely related sugar alcohols
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DISEASE     MIM: 182500  Sorbitol dehydrogenase; ?Cataract, congenital (2)
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVAC]
GENES       BSU: gutB
            SCE: YJR159W(SOR1) YKL148C(SDH1)
            HSA: SORD(Hs.878)
STRUCTURES  PDB: 1SDG  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.14
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.14
            SCOP (Structural Classificaion of Proteins): 1.1.1.14
///